FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146560814> ?p ?o ?g. }

• W2146560814 endingPage "37" @default.
• W2146560814 startingPage "37" @default.
• W2146560814 abstract "The Saccharopolyspora erythraea genome sequence, recently published, presents considerable divergence from those of streptomycetes in gene organization and function, confirming the remarkable potential of S. erythraea for producing many other secondary metabolites in addition to erythromycin. In order to investigate, at whole transcriptome level, how S. erythraea genes are modulated, a DNA microarray was specifically designed and constructed on the S. erythraea strain NRRL 2338 genome sequence, and the expression profiles of 6494 ORFs were monitored during growth in complex liquid medium.The transcriptional analysis identified a set of 404 genes, whose transcriptional signals vary during growth and characterize three distinct phases: a rapid growth until 32 h (Phase A); a growth slowdown until 52 h (Phase B); and another rapid growth phase from 56 h to 72 h (Phase C) before the cells enter the stationary phase. A non-parametric statistical method, that identifies chromosomal regions with transcriptional imbalances, determined regional organization of transcription along the chromosome, highlighting differences between core and non-core regions, and strand specific patterns of expression. Microarray data were used to characterize the temporal behaviour of major functional classes and of all the gene clusters for secondary metabolism. The results confirmed that the ery cluster is up-regulated during Phase A and identified six additional clusters (for terpenes and non-ribosomal peptides) that are clearly regulated in later phases.The use of a S. erythraea DNA microarray improved specificity and sensitivity of gene expression analysis, allowing a global and at the same time detailed picture of how S. erythraea genes are modulated. This work underlines the importance of using DNA microarrays, coupled with an exhaustive statistical and bioinformatic analysis of the results, to understand the transcriptional organization of the chromosomes of micro-organisms producing natural products." @default.
• W2146560814 created "2016-06-24" @default.
• W2146560814 creator A5002559498 @default.
• W2146560814 creator A5034654303 @default.
• W2146560814 creator A5046167293 @default.
• W2146560814 creator A5052141168 @default.
• W2146560814 creator A5060650777 @default.
• W2146560814 creator A5062054067 @default.
• W2146560814 creator A5066133225 @default.
• W2146560814 creator A5069595808 @default.
• W2146560814 creator A5076496892 @default.
• W2146560814 creator A5079506878 @default.
• W2146560814 creator A5084518228 @default.
• W2146560814 date "2007-01-01" @default.
• W2146560814 modified "2023-10-17" @default.
• W2146560814 title "Complete gene expression profiling of Saccharopolyspora erythraea using GeneChip DNA microarrays" @default.
• W2146560814 cites W1498991349 @default.
• W2146560814 cites W1539580523 @default.
• W2146560814 cites W1550215080 @default.
• W2146560814 cites W1964895626 @default.
• W2146560814 cites W1965315943 @default.
• W2146560814 cites W1970413517 @default.
• W2146560814 cites W1981550652 @default.
• W2146560814 cites W1987950188 @default.
• W2146560814 cites W1993228850 @default.
• W2146560814 cites W1996869411 @default.
• W2146560814 cites W1999670767 @default.
• W2146560814 cites W2008343440 @default.
• W2146560814 cites W2009156161 @default.
• W2146560814 cites W2012960603 @default.
• W2146560814 cites W2027146244 @default.
• W2146560814 cites W2038437697 @default.
• W2146560814 cites W2040967202 @default.
• W2146560814 cites W2055043387 @default.
• W2146560814 cites W2062609726 @default.
• W2146560814 cites W2081418090 @default.
• W2146560814 cites W2096567244 @default.
• W2146560814 cites W2101967572 @default.
• W2146560814 cites W2117732632 @default.
• W2146560814 cites W2128114769 @default.
• W2146560814 cites W2132020423 @default.
• W2146560814 cites W2132195303 @default.
• W2146560814 cites W2132324858 @default.
• W2146560814 cites W2137790941 @default.
• W2146560814 cites W2142925821 @default.
• W2146560814 cites W2149566602 @default.
• W2146560814 cites W2155687799 @default.
• W2146560814 cites W2161155802 @default.
• W2146560814 cites W2165011536 @default.
• W2146560814 cites W2170989872 @default.
• W2146560814 cites W45534775 @default.
• W2146560814 doi "https://doi.org/10.1186/1475-2859-6-37" @default.
• W2146560814 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2206050" @default.
• W2146560814 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18039355" @default.
• W2146560814 hasPublicationYear "2007" @default.
• W2146560814 type Work @default.
• W2146560814 sameAs 2146560814 @default.
• W2146560814 citedByCount "26" @default.
• W2146560814 countsByYear W21465608142012 @default.
• W2146560814 countsByYear W21465608142013 @default.
• W2146560814 countsByYear W21465608142014 @default.
• W2146560814 countsByYear W21465608142015 @default.
• W2146560814 countsByYear W21465608142016 @default.
• W2146560814 countsByYear W21465608142017 @default.
• W2146560814 countsByYear W21465608142018 @default.
• W2146560814 countsByYear W21465608142022 @default.
• W2146560814 crossrefType "journal-article" @default.
• W2146560814 hasAuthorship W2146560814A5002559498 @default.
• W2146560814 hasAuthorship W2146560814A5034654303 @default.
• W2146560814 hasAuthorship W2146560814A5046167293 @default.
• W2146560814 hasAuthorship W2146560814A5052141168 @default.
• W2146560814 hasAuthorship W2146560814A5060650777 @default.
• W2146560814 hasAuthorship W2146560814A5062054067 @default.
• W2146560814 hasAuthorship W2146560814A5066133225 @default.
• W2146560814 hasAuthorship W2146560814A5069595808 @default.
• W2146560814 hasAuthorship W2146560814A5076496892 @default.
• W2146560814 hasAuthorship W2146560814A5079506878 @default.
• W2146560814 hasAuthorship W2146560814A5084518228 @default.
• W2146560814 hasBestOaLocation W21465608141 @default.
• W2146560814 hasConcept C104317684 @default.
• W2146560814 hasConcept C141231307 @default.
• W2146560814 hasConcept C150194340 @default.
• W2146560814 hasConcept C162317418 @default.
• W2146560814 hasConcept C18431079 @default.
• W2146560814 hasConcept C36857842 @default.
• W2146560814 hasConcept C54355233 @default.
• W2146560814 hasConcept C70721500 @default.
• W2146560814 hasConcept C86803240 @default.
• W2146560814 hasConcept C95371953 @default.
• W2146560814 hasConceptScore W2146560814C104317684 @default.
• W2146560814 hasConceptScore W2146560814C141231307 @default.
• W2146560814 hasConceptScore W2146560814C150194340 @default.
• W2146560814 hasConceptScore W2146560814C162317418 @default.
• W2146560814 hasConceptScore W2146560814C18431079 @default.
• W2146560814 hasConceptScore W2146560814C36857842 @default.
• W2146560814 hasConceptScore W2146560814C54355233 @default.
• W2146560814 hasConceptScore W2146560814C70721500 @default.
• W2146560814 hasConceptScore W2146560814C86803240 @default.

• next