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- W2146566696 abstract "Pyrexia is one of the most common symptomatic presentations of disease. A lot of research is going on worldwide towards findi ng antipyretic agents from natural so urces. The aim of this study wa s to screen the antipyretic effect of aqueous and ethanol leaf extract of Cassia alata . The leaves of Cassia alata was collected, dried, ground and extracted using water and 95% ethanol at which the extracts was used for the antipyretic screening. Brewer’s yeast was used to induce pyrexia at which the rectal temperature of the rats was taken after the oral ad ministration of the varying doses of the extracts. The reduction in temperature by the extracts was dose dependent wit h ethanol having higher percentage reduction compared with the water extract. At 400 mg/kg of ethanol extract , the reduction in pyrexia after 30 and 60 minutes was 137% and 167% respectively which was significantly higher than the paracetamol (75% and 122 %) used as a positive control (p<0.05). It is evident from the results of this finding that the crude aqueous and ethanol leaf extracts of Cassia alata contains bioactive constituents that may be responsible for the antipyretic activity observed, thus just ifying its uses in traditional medicine." @default.
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- W2146566696 date "2012-12-21" @default.
- W2146566696 modified "2023-09-26" @default.
- W2146566696 title "ANTIPYRETIC ACTIVITY OF AQUEOUS AND ETHANOLIC EXTRACT OF CASSIA ALATA LINN LEAF" @default.
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- W2146566696 doi "https://doi.org/10.7897/2277-4343.03625" @default.
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