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- W2146603603 abstract "Theadjuvant activity ofBordetella pertussis wasinvestigated, bothatthecellular andhumoral levels, whenthebacterial adjuvant wasgiven atvarious times after the primary antigenic stimulus ofboth2 X 107(suboptimal dose) and4 x 108(optimal dose) ofsheep erythrocytes. Inallexperiments, bothadjuvant andsheep erythrocytes wereadministered bytheintraperitoneal route. Adjuvant activity wasmeasured on thebasis oftheearly andlate phases oftheprimary responseandon thedegree ofpriming forthesecondary immunereaction. A maximal adjuvant activity was foundinmicewhichhadreceived B.pertussis vaccine simultaneously withthe antigen. Adiuvant effectiveness becameless asthetimeinterval between theinjection ofantigen andadjuvant increased. Adjuvancy alsodepended on theamountof antigen usedastheprimary antigenic stimulus. With4 x 108sheeperythrocytes, significantly increased priming forthesecondary responsewasproduced onlywhen B.pertussis cellswereadministered within a period of24hr.Whenthebacterial adjuvant was administered either 48or72hrafter theprimary antigenic stimulus, adiuvancy was found tobelimited tothelate phase oftheprimary responseandto theprolonged development ofantibody-forming cells during thesecondary immune reaction. Incontrast, significantly enhanced priming forthesecondary response was detectable whentheadjuvant was administered as late as48hrafter primary immunization with2 X 107sheep erythrocytes. Whenthebacterial adjuvant was administered either 6,24,48, or72hrafter theprimary immunization with2 X 107 sheep erythrocytes, theearly phase oftheprimary 19Sand7Shemolysin response was foundtobesuppressed, andadjuvancy becamedetectable onlythereafter." @default.
- W2146603603 created "2016-06-24" @default.
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- W2146603603 date "1972-01-01" @default.
- W2146603603 modified "2023-09-27" @default.
- W2146603603 title "TimeRelationships BetweenInjection ofAntigen andAdjuvant III. Adjuvancy ofBordetella pertussis GivenatVarious TimesAfter the Primary Antigenic Stimulus" @default.
- W2146603603 cites W1535184892 @default.
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