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• W2146607002 abstract "Abstract Aim The aim of the present study was to evaluate the influence of the baseline detection of A ggregatibacter actinomycetemcomitans ( A . actinomycetemcomitans ) on the clinical outcomes of moxifloxacin ( MOX ) as an adjunct to full‐mouth scaling and root planing ( SRP ) in generalized aggressive periodontitis ( GA g P ). Methods Forty patients were randomly distributed to two therapy protocols: SRP + placebo or SRP combined with MOX . A . actinomycetemcomitans was detected using culture methods. The significance of the treatment option ( MOX or SRP + placebo) on the dependent variables (probing depth [ PD ] and clinical attachment level [ CAL ]), considering the interaction with the baseline detection of A . actinomycetemcomitans , was estimated. Results MOX therapy led to a higher significant PD reduction and CAL gain in A . actinomycetemcomitans ‐positive patients at baseline. In A . actinomycetemcomitans ‐positive patients, the reduction of sites ≥5 mm was higher in the MOX group. A . actinomycetemcomitans was not present in sites with PD ≥6 mm in the MOX group. The interactions of A . actinomycetemcomitans and MOX were significantly associated with CAL gain and PD reduction at 6 months. Conclusions Adjunctive MOX trended toward better clinical responses in A . actinomycetemcomitans ‐positive patients at baseline. These results suggest that A . actinomycetemcomitans at baseline might modify the effect of adjunctive MOX in GA g P ." @default.
• W2146607002 created "2016-06-24" @default.
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• W2146607002 date "2015-11-05" @default.
• W2146607002 modified "2023-10-03" @default.
• W2146607002 title "Benefits of adjunctive moxifloxacin in generalized aggressive periodontitis: a subgroup analyses in<i>Aggregatibacter actinomycetemcomitans</i>-positive/negative patients from a clinical trial" @default.
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• W2146607002 doi "https://doi.org/10.1111/jicd.12197" @default.
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