Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146633499> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2146633499 endingPage "164" @default.
- W2146633499 startingPage "161" @default.
- W2146633499 abstract "Asynchronous activation of the ventricles deteriorates cardiac function acutely, followed by further worsening over time. In a multi-scale model we tested the hypothesis that the second phase is due to mechano-electrical coupling (MEC), mediated by remodeling of ionic membrane currents. Our model describes hemodynamic interaction between the left and right ventricle as well as mechanical interaction of three wall segments. At cellular level, excitation-contraction coupling is described by a cascade of physiological models. At the organ level, pressure-volume relations are obtained by simulating the pulmonary and systemic circulation. MEC is incorporated by local adaptation of L-type Ca2+ current to local mechanical load. Our model predicts that MEC has no effect on cardiac function in the heart with normal conduction, but leads to reduced pump function in the asynchronous heart. We conclude that MEC may aggravate the consequences of abnormal electrical activation in the long run." @default.
- W2146633499 created "2016-06-24" @default.
- W2146633499 creator A5032735078 @default.
- W2146633499 creator A5070707413 @default.
- W2146633499 creator A5077723414 @default.
- W2146633499 creator A5080175953 @default.
- W2146633499 date "2011-09-01" @default.
- W2146633499 modified "2023-09-26" @default.
- W2146633499 title "Mechano-electrical coupling explains worsening of cardiac function in the asynchronous heart" @default.
- W2146633499 cites W1980972090 @default.
- W2146633499 cites W1993544662 @default.
- W2146633499 cites W2017138224 @default.
- W2146633499 cites W2022919976 @default.
- W2146633499 cites W2036373717 @default.
- W2146633499 cites W2038769531 @default.
- W2146633499 cites W2058465462 @default.
- W2146633499 cites W2063039489 @default.
- W2146633499 cites W2071208293 @default.
- W2146633499 cites W2086061329 @default.
- W2146633499 cites W2111879981 @default.
- W2146633499 cites W2116898972 @default.
- W2146633499 cites W2128070479 @default.
- W2146633499 cites W2130321115 @default.
- W2146633499 cites W2149215994 @default.
- W2146633499 cites W2163071496 @default.
- W2146633499 cites W2170281616 @default.
- W2146633499 cites W2188240824 @default.
- W2146633499 hasPublicationYear "2011" @default.
- W2146633499 type Work @default.
- W2146633499 sameAs 2146633499 @default.
- W2146633499 citedByCount "1" @default.
- W2146633499 countsByYear W21466334992014 @default.
- W2146633499 crossrefType "journal-article" @default.
- W2146633499 hasAuthorship W2146633499A5032735078 @default.
- W2146633499 hasAuthorship W2146633499A5070707413 @default.
- W2146633499 hasAuthorship W2146633499A5077723414 @default.
- W2146633499 hasAuthorship W2146633499A5080175953 @default.
- W2146633499 hasConcept C126322002 @default.
- W2146633499 hasConcept C131584629 @default.
- W2146633499 hasConcept C136229726 @default.
- W2146633499 hasConcept C164705383 @default.
- W2146633499 hasConcept C178853913 @default.
- W2146633499 hasConcept C191897082 @default.
- W2146633499 hasConcept C192562407 @default.
- W2146633499 hasConcept C2778921608 @default.
- W2146633499 hasConcept C2910288590 @default.
- W2146633499 hasConcept C39133596 @default.
- W2146633499 hasConcept C71924100 @default.
- W2146633499 hasConcept C99398487 @default.
- W2146633499 hasConceptScore W2146633499C126322002 @default.
- W2146633499 hasConceptScore W2146633499C131584629 @default.
- W2146633499 hasConceptScore W2146633499C136229726 @default.
- W2146633499 hasConceptScore W2146633499C164705383 @default.
- W2146633499 hasConceptScore W2146633499C178853913 @default.
- W2146633499 hasConceptScore W2146633499C191897082 @default.
- W2146633499 hasConceptScore W2146633499C192562407 @default.
- W2146633499 hasConceptScore W2146633499C2778921608 @default.
- W2146633499 hasConceptScore W2146633499C2910288590 @default.
- W2146633499 hasConceptScore W2146633499C39133596 @default.
- W2146633499 hasConceptScore W2146633499C71924100 @default.
- W2146633499 hasConceptScore W2146633499C99398487 @default.
- W2146633499 hasLocation W21466334991 @default.
- W2146633499 hasOpenAccess W2146633499 @default.
- W2146633499 hasPrimaryLocation W21466334991 @default.
- W2146633499 hasRelatedWork W1817629408 @default.
- W2146633499 hasRelatedWork W2022812070 @default.
- W2146633499 hasRelatedWork W2047538101 @default.
- W2146633499 hasRelatedWork W2063039489 @default.
- W2146633499 hasRelatedWork W2067387896 @default.
- W2146633499 hasRelatedWork W2099821724 @default.
- W2146633499 hasRelatedWork W2101289795 @default.
- W2146633499 hasRelatedWork W2105954132 @default.
- W2146633499 hasRelatedWork W2108708256 @default.
- W2146633499 hasRelatedWork W2115746499 @default.
- W2146633499 hasRelatedWork W2118671666 @default.
- W2146633499 hasRelatedWork W2153285041 @default.
- W2146633499 hasRelatedWork W2162081752 @default.
- W2146633499 hasRelatedWork W2264356421 @default.
- W2146633499 hasRelatedWork W2488632039 @default.
- W2146633499 hasRelatedWork W2790641085 @default.
- W2146633499 hasRelatedWork W3141978595 @default.
- W2146633499 hasRelatedWork W3146973048 @default.
- W2146633499 hasRelatedWork W3171728076 @default.
- W2146633499 hasRelatedWork W2133755319 @default.
- W2146633499 isParatext "false" @default.
- W2146633499 isRetracted "false" @default.
- W2146633499 magId "2146633499" @default.
- W2146633499 workType "article" @default.