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• W2146636701 abstract "During development of the central nervous system, oligodendrocyte progenitor cells (O-2A) undergo an orderly pattern of cell proliferation and differentiation, culminating in the ability of oligodendrocytes to myelinate axons. Here we report that p27 Kip1 , a cyclin-dependent kinase inhibitor, is an important component of the decision of O-2A cells to withdraw from the cell cycle. In vitro, accumulation of p27 correlates with differentiation of oligodendrocytes. Furthermore, only a fraction of O-2A cells derived from p27-knockout mice differentiate successfully compared to controls. Inability to differentiate correlates with continued proliferation, suggesting that p27 is an important component of the machinery required for the G 1 /G 0 transition in O-2A cells. In vivo, expansion of O-2A precursors before withdrawal, in part, leads to a greater number of oligodendrocytes. Together these data indicate a role for p27 during the decision to withdraw from the cell cycle in the oligodendrocyte lineage." @default.
• W2146636701 created "2016-06-24" @default.
• W2146636701 creator A5002612058 @default.
• W2146636701 creator A5011452621 @default.
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• W2146636701 creator A5045667476 @default.
• W2146636701 creator A5055604858 @default.
• W2146636701 creator A5083842270 @default.
• W2146636701 date "1997-09-15" @default.
• W2146636701 modified "2023-09-29" @default.
• W2146636701 title "Oligodendrocyte precursor differentiation is perturbed in the absence of the cyclin-dependent kinase inhibitor p27^Kip1" @default.
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• W2146636701 doi "https://doi.org/10.1101/gad.11.18.2335" @default.
• W2146636701 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/316517" @default.
• W2146636701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9308962" @default.
• W2146636701 hasPublicationYear "1997" @default.
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