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- W2146643775 abstract "The mechanisms underlying the decision of a stem or progenitor cell to either self-renew or differentiate are incompletely understood. To address the role of Myc in this process, we expressed different forms of the proto-oncogene Myc in multipotent neural progenitor cells (NPCs) using retroviral transduction. Expression of Myc in neurospheres increased the proportion of self-renewing cells fivefold, and 1% of the Myc-overexpressing cells, but none of the control cells, retained self-renewal capacity even under differentiation-inducing conditions. A Myc mutant (MycV394D) deficient in binding to Miz-1, did not increase the percentage of self-renewing cells but was able to stimulate proliferation of NPCs as efficiently as wild-type Myc, indicating that these two cellular phenomena are regulated by at least partially different pathways. Our results suggest that Myc, through Miz-1, enhances self-renewal of NPCs and influences the way progenitor cells react to the environmental cues that normally dictate the cellular identity of tissues containing self-renewing cells." @default.
- W2146643775 created "2016-06-24" @default.
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- W2146643775 date "2008-12-01" @default.
- W2146643775 modified "2023-10-18" @default.
- W2146643775 title "Myc increases self-renewal in neural progenitor cells through Miz-1" @default.
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- W2146643775 doi "https://doi.org/10.1242/jcs.024802" @default.
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