FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146644116> ?p ?o ?g. }

• W2146644116 endingPage "4625" @default.
• W2146644116 startingPage "4613" @default.
• W2146644116 abstract "The extrarenal synthesis of 1α,25 dihydroxyvitamin D3 (1,25D) has been demonstrated in a number of cell types including osteoblasts and cells of the monocyte/macrophage lineage. The skeleton appears responsive to serum levels of the 1,25D precursor, 25 hydroxyvitamin D3 (25D), in terms of bone mineralization parameters. The effect of metabolism of 25D into active 1,25D by osteoclast lineage cells is unknown. We found that CYP27B1 mRNA expression increased with exposure of human peripheral blood mononuclear cells (PBMCs) to macrophage colony-stimulating factor in the presence or absence of receptor activator of nuclear factor-κB ligand. Consistent with this, human osteoclast cultures incubated with 25D produced measurable quantities of 1,25D. Osteoclast formation from either mouse RAW264.7 cells or human PBMCs in the presence of physiological concentrations of 25D resulted in significant up-regulation of the key osteoclast transcription factor, nuclear factor of activated T cells-c1 in PBMCs and a number of key osteoclast marker genes in both models. The expression of the osteoblast coupling factor, ephrin-b2, was also increased in the presence of 25D. Levels of CYP27B1 and nuclear factor of activated T cells-1 mRNA correlated during osteoclastogenesis and also in a cohort of human bone samples. CYP27B1 short-hairpin RNA knockdown in RAW264.7 cells decreased their osteoclastogenic potential. 25D dose dependently reduced the resorptive capacity of PBMC-derived osteoclasts without compromising cell viability. 25D also reduced resorption by RAW264.7- and giant cell tumor-derived osteoclasts. Conversely, osteoclasts formed from vitamin D receptor-null mouse splenocytes had increased resorptive activity compared with wild-type cells. We conclude that 25D metabolism is an important intrinsic mechanism for optimizing osteoclast differentiation, ameliorating osteoclast activity, and potentially promoting the coupling of bone resorption to formation." @default.
• W2146644116 created "2016-06-24" @default.
• W2146644116 creator A5007685204 @default.
• W2146644116 creator A5023571108 @default.
• W2146644116 creator A5025428521 @default.
• W2146644116 creator A5041210425 @default.
• W2146644116 creator A5051520123 @default.
• W2146644116 creator A5063174984 @default.
• W2146644116 creator A5065929346 @default.
• W2146644116 date "2010-08-25" @default.
• W2146644116 modified "2023-10-11" @default.
• W2146644116 title "Osteoclastic Metabolism of 25(OH)-Vitamin D3: A Potential Mechanism for Optimization of Bone Resorption" @default.
• W2146644116 cites W1486598646 @default.
• W2146644116 cites W1543525745 @default.
• W2146644116 cites W1623258939 @default.
• W2146644116 cites W1964234958 @default.
• W2146644116 cites W1964306502 @default.
• W2146644116 cites W1969065492 @default.
• W2146644116 cites W1971755627 @default.
• W2146644116 cites W1973291424 @default.
• W2146644116 cites W1975505424 @default.
• W2146644116 cites W1976183788 @default.
• W2146644116 cites W1984758198 @default.
• W2146644116 cites W1986784478 @default.
• W2146644116 cites W1989700145 @default.
• W2146644116 cites W1990935283 @default.
• W2146644116 cites W1996116098 @default.
• W2146644116 cites W1996348498 @default.
• W2146644116 cites W1997581290 @default.
• W2146644116 cites W1999237472 @default.
• W2146644116 cites W2001740011 @default.
• W2146644116 cites W2002353852 @default.
• W2146644116 cites W2003287315 @default.
• W2146644116 cites W2014881074 @default.
• W2146644116 cites W2017372504 @default.
• W2146644116 cites W2017957968 @default.
• W2146644116 cites W2018350290 @default.
• W2146644116 cites W2019213459 @default.
• W2146644116 cites W2026387061 @default.
• W2146644116 cites W2044884069 @default.
• W2146644116 cites W2045258828 @default.
• W2146644116 cites W2046340099 @default.
• W2146644116 cites W2046473453 @default.
• W2146644116 cites W2054152152 @default.
• W2146644116 cites W2055730405 @default.
• W2146644116 cites W2063680739 @default.
• W2146644116 cites W2064714960 @default.
• W2146644116 cites W2072917762 @default.
• W2146644116 cites W2078973452 @default.
• W2146644116 cites W2082942825 @default.
• W2146644116 cites W2087575862 @default.
• W2146644116 cites W2089042902 @default.
• W2146644116 cites W2089763656 @default.
• W2146644116 cites W2092448698 @default.
• W2146644116 cites W2094149537 @default.
• W2146644116 cites W2097743908 @default.
• W2146644116 cites W2101422590 @default.
• W2146644116 cites W2104882573 @default.
• W2146644116 cites W2106766464 @default.
• W2146644116 cites W2109608328 @default.
• W2146644116 cites W2110690276 @default.
• W2146644116 cites W2125523177 @default.
• W2146644116 cites W2132408993 @default.
• W2146644116 cites W2139066042 @default.
• W2146644116 cites W2161111422 @default.
• W2146644116 cites W2169970337 @default.
• W2146644116 cites W2403650199 @default.
• W2146644116 cites W4234005853 @default.
• W2146644116 doi "https://doi.org/10.1210/en.2010-0334" @default.
• W2146644116 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20739402" @default.
• W2146644116 hasPublicationYear "2010" @default.
• W2146644116 type Work @default.
• W2146644116 sameAs 2146644116 @default.
• W2146644116 citedByCount "122" @default.
• W2146644116 countsByYear W21466441162012 @default.
• W2146644116 countsByYear W21466441162013 @default.
• W2146644116 countsByYear W21466441162014 @default.
• W2146644116 countsByYear W21466441162015 @default.
• W2146644116 countsByYear W21466441162016 @default.
• W2146644116 countsByYear W21466441162017 @default.
• W2146644116 countsByYear W21466441162018 @default.
• W2146644116 countsByYear W21466441162019 @default.
• W2146644116 countsByYear W21466441162020 @default.
• W2146644116 countsByYear W21466441162021 @default.
• W2146644116 countsByYear W21466441162022 @default.
• W2146644116 countsByYear W21466441162023 @default.
• W2146644116 crossrefType "journal-article" @default.
• W2146644116 hasAuthorship W2146644116A5007685204 @default.
• W2146644116 hasAuthorship W2146644116A5023571108 @default.
• W2146644116 hasAuthorship W2146644116A5025428521 @default.
• W2146644116 hasAuthorship W2146644116A5041210425 @default.
• W2146644116 hasAuthorship W2146644116A5051520123 @default.
• W2146644116 hasAuthorship W2146644116A5063174984 @default.
• W2146644116 hasAuthorship W2146644116A5065929346 @default.
• W2146644116 hasBestOaLocation W21466441161 @default.
• W2146644116 hasConcept C124490489 @default.
• W2146644116 hasConcept C126322002 @default.
• W2146644116 hasConcept C134018914 @default.

• next