FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146644291> ?p ?o ?g. }

• W2146644291 endingPage "2232" @default.
• W2146644291 startingPage "2219" @default.
• W2146644291 abstract "Abstract The relationships between reproduction and aging are important for understanding the mechanisms of aging and evaluating evolutionary theories of aging. To investigate the effects of progeny production on reproductive and somatic aging, we conducted longitudinal studies of Caenorhabditis elegans hermaphrodites. For mated wild-type animals that were not sperm limited and survived past the end of the reproductive period, high levels of cross-progeny production were positively correlated with delayed reproductive and somatic aging. In this group of animals, individuals that generated more cross progeny also reproduced and lived longer than individuals that generated fewer cross progeny. These results indicate that progeny production does not accelerate reproductive or somatic aging. This longitudinal study demonstrated that cumulative cross progeny production through day four is an early-stage biomarker that is a positive predictor of longevity. Furthermore, in mated animals, high levels of early cross progeny production were positively correlated with high levels of late cross progeny production, indicating that early progeny production does not accelerate reproductive aging. The relationships between progeny production and aging were further evaluated by comparing self-fertile hermaphrodites that generated relatively few self progeny with mated hermaphrodites that generated many cross progeny. The timing of age-related somatic degeneration was similar in these groups, suggesting progeny production does not accelerate somatic aging. These studies rigorously define relationships between progeny production, reproductive aging, and somatic aging and identify new biomarkers of C. elegans aging. These results indicate that some mechanisms or pathways control age-related degeneration of both reproductive and somatic tissues in C. elegans." @default.
• W2146644291 created "2016-06-24" @default.
• W2146644291 creator A5019581350 @default.
• W2146644291 creator A5053309905 @default.
• W2146644291 creator A5054917382 @default.
• W2146644291 creator A5072831824 @default.
• W2146644291 creator A5044074952 @default.
• W2146644291 date "2013-12-01" @default.
• W2146644291 modified "2023-10-13" @default.
• W2146644291 title "Mated Progeny Production Is a Biomarker of Aging in<i>Caenorhabditis elegans</i>" @default.
• W2146644291 cites W1571291351 @default.
• W2146644291 cites W1619158228 @default.
• W2146644291 cites W1812816875 @default.
• W2146644291 cites W1899108571 @default.
• W2146644291 cites W1944127002 @default.
• W2146644291 cites W1948560580 @default.
• W2146644291 cites W1963816832 @default.
• W2146644291 cites W1966145280 @default.
• W2146644291 cites W1971197630 @default.
• W2146644291 cites W1976416661 @default.
• W2146644291 cites W1985647060 @default.
• W2146644291 cites W1993091967 @default.
• W2146644291 cites W2001908075 @default.
• W2146644291 cites W2004244220 @default.
• W2146644291 cites W2006384398 @default.
• W2146644291 cites W2012222058 @default.
• W2146644291 cites W2015202087 @default.
• W2146644291 cites W2018096301 @default.
• W2146644291 cites W2023095530 @default.
• W2146644291 cites W2025461446 @default.
• W2146644291 cites W2034734284 @default.
• W2146644291 cites W2034924573 @default.
• W2146644291 cites W2037126619 @default.
• W2146644291 cites W2037741962 @default.
• W2146644291 cites W2042311470 @default.
• W2146644291 cites W2042474311 @default.
• W2146644291 cites W2042986568 @default.
• W2146644291 cites W2043476437 @default.
• W2146644291 cites W2046989794 @default.
• W2146644291 cites W2054059225 @default.
• W2146644291 cites W2055937273 @default.
• W2146644291 cites W2057895311 @default.
• W2146644291 cites W2058127437 @default.
• W2146644291 cites W2058484936 @default.
• W2146644291 cites W2067441678 @default.
• W2146644291 cites W2075415421 @default.
• W2146644291 cites W2077440549 @default.
• W2146644291 cites W2080802801 @default.
• W2146644291 cites W2080956060 @default.
• W2146644291 cites W2085230335 @default.
• W2146644291 cites W2087169316 @default.
• W2146644291 cites W2088119447 @default.
• W2146644291 cites W2089325551 @default.
• W2146644291 cites W2093588915 @default.
• W2146644291 cites W2096570816 @default.
• W2146644291 cites W2097949591 @default.
• W2146644291 cites W2098124125 @default.
• W2146644291 cites W2100365580 @default.
• W2146644291 cites W2107978848 @default.
• W2146644291 cites W2123759661 @default.
• W2146644291 cites W2123974476 @default.
• W2146644291 cites W2128375367 @default.
• W2146644291 cites W2135479055 @default.
• W2146644291 cites W2147997150 @default.
• W2146644291 cites W2148966035 @default.
• W2146644291 cites W2153376904 @default.
• W2146644291 cites W2155000552 @default.
• W2146644291 cites W2160412869 @default.
• W2146644291 cites W2161879400 @default.
• W2146644291 cites W2186908650 @default.
• W2146644291 cites W2316973238 @default.
• W2146644291 cites W2791605128 @default.
• W2146644291 doi "https://doi.org/10.1534/g3.113.008664" @default.
• W2146644291 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3852384" @default.
• W2146644291 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24142929" @default.
• W2146644291 hasPublicationYear "2013" @default.
• W2146644291 type Work @default.
• W2146644291 sameAs 2146644291 @default.
• W2146644291 citedByCount "33" @default.
• W2146644291 countsByYear W21466442912014 @default.
• W2146644291 countsByYear W21466442912015 @default.
• W2146644291 countsByYear W21466442912016 @default.
• W2146644291 countsByYear W21466442912017 @default.
• W2146644291 countsByYear W21466442912018 @default.
• W2146644291 countsByYear W21466442912019 @default.
• W2146644291 countsByYear W21466442912020 @default.
• W2146644291 countsByYear W21466442912021 @default.
• W2146644291 countsByYear W21466442912022 @default.
• W2146644291 countsByYear W21466442912023 @default.
• W2146644291 crossrefType "journal-article" @default.
• W2146644291 hasAuthorship W2146644291A5019581350 @default.
• W2146644291 hasAuthorship W2146644291A5044074952 @default.
• W2146644291 hasAuthorship W2146644291A5053309905 @default.
• W2146644291 hasAuthorship W2146644291A5054917382 @default.
• W2146644291 hasAuthorship W2146644291A5072831824 @default.
• W2146644291 hasBestOaLocation W21466442911 @default.
• W2146644291 hasConcept C104317684 @default.
• W2146644291 hasConcept C134305767 @default.

• next