FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146646546> ?p ?o ?g. }

• W2146646546 endingPage "773" @default.
• W2146646546 startingPage "768" @default.
• W2146646546 abstract "Although the promising immunosuppressant, mycophenolic acid (MPA), has many desirable properties and is widely prescribed for organ transplant recipients, its high oral dosage requirement is not understood. Whereas previous Northern blot analysis by Basu and colleagues (2004) located the mRNAs encoding MPA primary metabolizers, UDP-glucuronosyltransferases (UGTs) 1A7, 1A8, 1A9, and 1A10, in human gastrointestinal (GI) tissues, in situ hybridization analysis of mRNAs found that the isozymes were restricted to the mucosal layer of various GI organs. Concomitantly, MPA was glucuronidated by microsomes isolated from normal adjoining specimens. Microsomal studies showed the highest relative rates of metabolism in esophagus, ileum, duodenum, colon, and stomach at pH 6.4; only esophagus showed high pH 7.6 activity. Properties of the recombinant UGTs indicate that MPA is metabolized with pH 6.4 or 7.6 optimum. Activity for 1A7 and 1A9 increased with increasing concentrations up to 2.4 mM, with parallel production of both ether- and acylglucuronides; similarly, 1A8 and 1A10 reached plateaus at 1.6 mM, producing both glucuronides. <i>K</i>_m values were 250 to 550 μM. Between 400 and 1600 μM MPA, isozymes generated between 15 and 42% of the acylglucuronides. In effect, high <i>K</i>_m values (MPA) are associated with high concentrations to achieve saturation kinetics. Finally, transient inhibition of UGTs in human LS180 colon cells and mouse duodenum by the dietary agent, curcumin, has implications for in vivo pretreatment to reduce MPA glucuronidation to increase the therapeutic index." @default.
• W2146646546 created "2016-06-24" @default.
• W2146646546 creator A5041976726 @default.
• W2146646546 creator A5049474126 @default.
• W2146646546 creator A5064115386 @default.
• W2146646546 creator A5075843827 @default.
• W2146646546 date "2004-06-17" @default.
• W2146646546 modified "2023-09-25" @default.
• W2146646546 title "HUMAN UDP-GLUCURONOSYLTRANSFERASES SHOW ATYPICAL METABOLISM OF MYCOPHENOLIC ACID AND INHIBITION BY CURCUMIN" @default.
• W2146646546 cites W1486575517 @default.
• W2146646546 cites W1929788581 @default.
• W2146646546 cites W1964468595 @default.
• W2146646546 cites W1974655274 @default.
• W2146646546 cites W1983694865 @default.
• W2146646546 cites W1985732783 @default.
• W2146646546 cites W1988891326 @default.
• W2146646546 cites W2002673669 @default.
• W2146646546 cites W2011780463 @default.
• W2146646546 cites W2013670635 @default.
• W2146646546 cites W2014239314 @default.
• W2146646546 cites W2027761686 @default.
• W2146646546 cites W2040946169 @default.
• W2146646546 cites W2060752790 @default.
• W2146646546 cites W2061904336 @default.
• W2146646546 cites W2064451454 @default.
• W2146646546 cites W2065676027 @default.
• W2146646546 cites W2079303074 @default.
• W2146646546 cites W2083855590 @default.
• W2146646546 cites W2092427799 @default.
• W2146646546 cites W2105427480 @default.
• W2146646546 cites W2106819409 @default.
• W2146646546 cites W2147965104 @default.
• W2146646546 cites W2609602266 @default.
• W2146646546 doi "https://doi.org/10.1124/dmd.32.7.768" @default.
• W2146646546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15205394" @default.
• W2146646546 hasPublicationYear "2004" @default.
• W2146646546 type Work @default.
• W2146646546 sameAs 2146646546 @default.
• W2146646546 citedByCount "65" @default.
• W2146646546 countsByYear W21466465462012 @default.
• W2146646546 countsByYear W21466465462013 @default.
• W2146646546 countsByYear W21466465462014 @default.
• W2146646546 countsByYear W21466465462015 @default.
• W2146646546 countsByYear W21466465462016 @default.
• W2146646546 countsByYear W21466465462017 @default.
• W2146646546 countsByYear W21466465462018 @default.
• W2146646546 countsByYear W21466465462019 @default.
• W2146646546 countsByYear W21466465462021 @default.
• W2146646546 countsByYear W21466465462022 @default.
• W2146646546 crossrefType "journal-article" @default.
• W2146646546 hasAuthorship W2146646546A5041976726 @default.
• W2146646546 hasAuthorship W2146646546A5049474126 @default.
• W2146646546 hasAuthorship W2146646546A5064115386 @default.
• W2146646546 hasAuthorship W2146646546A5075843827 @default.
• W2146646546 hasConcept C119795356 @default.
• W2146646546 hasConcept C126322002 @default.
• W2146646546 hasConcept C150903083 @default.
• W2146646546 hasConcept C181199279 @default.
• W2146646546 hasConcept C185592680 @default.
• W2146646546 hasConcept C207001950 @default.
• W2146646546 hasConcept C2776809568 @default.
• W2146646546 hasConcept C2777226302 @default.
• W2146646546 hasConcept C2779907587 @default.
• W2146646546 hasConcept C55493867 @default.
• W2146646546 hasConcept C62231903 @default.
• W2146646546 hasConcept C71924100 @default.
• W2146646546 hasConcept C86803240 @default.
• W2146646546 hasConcept C87644729 @default.
• W2146646546 hasConcept C98274493 @default.
• W2146646546 hasConceptScore W2146646546C119795356 @default.
• W2146646546 hasConceptScore W2146646546C126322002 @default.
• W2146646546 hasConceptScore W2146646546C150903083 @default.
• W2146646546 hasConceptScore W2146646546C181199279 @default.
• W2146646546 hasConceptScore W2146646546C185592680 @default.
• W2146646546 hasConceptScore W2146646546C207001950 @default.
• W2146646546 hasConceptScore W2146646546C2776809568 @default.
• W2146646546 hasConceptScore W2146646546C2777226302 @default.
• W2146646546 hasConceptScore W2146646546C2779907587 @default.
• W2146646546 hasConceptScore W2146646546C55493867 @default.
• W2146646546 hasConceptScore W2146646546C62231903 @default.
• W2146646546 hasConceptScore W2146646546C71924100 @default.
• W2146646546 hasConceptScore W2146646546C86803240 @default.
• W2146646546 hasConceptScore W2146646546C87644729 @default.
• W2146646546 hasConceptScore W2146646546C98274493 @default.
• W2146646546 hasIssue "7" @default.
• W2146646546 hasLocation W21466465461 @default.
• W2146646546 hasLocation W21466465462 @default.
• W2146646546 hasOpenAccess W2146646546 @default.
• W2146646546 hasPrimaryLocation W21466465461 @default.
• W2146646546 hasRelatedWork W1959677388 @default.
• W2146646546 hasRelatedWork W1965614386 @default.
• W2146646546 hasRelatedWork W2009067244 @default.
• W2146646546 hasRelatedWork W2010247428 @default.
• W2146646546 hasRelatedWork W2140054248 @default.
• W2146646546 hasRelatedWork W2147593455 @default.
• W2146646546 hasRelatedWork W2246940898 @default.
• W2146646546 hasRelatedWork W2412584354 @default.
• W2146646546 hasRelatedWork W2429350156 @default.

• next