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- W2146648081 abstract "Five male patients, aged 52 to 61 years, with severely photodamaged forearm skin received 0.05% tretinoin cream twice daily for 1 month. The following procedures were done before and after treatment: (1) 3-mm punch biopsies for histochemical evaluation, (2) sticky slides to determine the degree of melanization of corneocytes, (3) detergent scrubs for corneocyte sizing and morphological evaluation, and (4) Silflo replicas for surface topography visualization. A modest improvement in surface texture was observed. By contrast, histological changes were striking. Epidermal abnormalities were largely corrected. Atypia and dysplasia were eliminated, accompanied by acanthosis restoration of polarity and a thinned horny layer. Dermal changes were insignificant. Glyphic patterns were shown to have redeveloped in replicas of the skin surface. Melanin granules within corneocytes decreased sharply; this was associated with modest bleaching of pigmented spots. Thus it was demonstrated that the typical effects of tretinoin on epidermal abnormalities of photodamaged skin can be discerned after only 1 month of treatment." @default.
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- W2146648081 date "1993-01-01" @default.
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- W2146648081 title "The effect of short-term (one-month) topical tretinoin on photodamaged forearm skin" @default.
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- W2146648081 doi "https://doi.org/10.3109/09546639309080553" @default.
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