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• W2146651745 endingPage "1689" @default.
• W2146651745 startingPage "1683" @default.
• W2146651745 abstract "Royal jelly (RJ) has various pharmacological actions, including hypolipidaemic, hypocholesterolaemic and anti-atherosclerotic effects, in experimental animals but the molecular mechanisms involved remain unclear. Here, we investigated changes in the expression of lipid metabolism-associated genes in the liver of RJ-treated mice by means of a DNA microarray technique to obtain clues to the mechanism of the hypocholesterolaemic action of RJ. We compared the hepatic gene expression profiles in three groups of mice fed a diet containing 5% RJ, a diet containing 5% RJ stored at 40 degrees C for 7 days (40-7d RJ) or a control diet which provided the same total energy as the other diets. RJ decreased gene expression of squalene epoxidase (SQLE), which is a key enzyme in cholesterol biosynthesis, and sterol regulatory element-binding protein (SREB)-1, which may be a transcriptional factor of SQLE. It increased gene expression of low-density lipoprotein receptor (LDLR), which is involved in cholesterol incorporation in liver. Thus, the hypocholesterolaemic action of RJ appears to be associated with a decrease of SQLE and an increase of LDLR in mice." @default.
• W2146651745 created "2016-06-24" @default.
• W2146651745 creator A5022359679 @default.
• W2146651745 creator A5036846494 @default.
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• W2146651745 date "2006-12-01" @default.
• W2146651745 modified "2023-10-13" @default.
• W2146651745 title "Changes in hepatic gene expression associated with the hypocholesterolaemic activity of royal jelly" @default.
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• W2146651745 doi "https://doi.org/10.1211/jpp.58.12.0017" @default.
• W2146651745 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17331334" @default.
• W2146651745 hasPublicationYear "2006" @default.
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