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- W2146656704 endingPage "1286" @default.
- W2146656704 startingPage "1273" @default.
- W2146656704 abstract "The increasing evidence that inflammation in the lungs leads to the structural changes observed in chronic obstructive pulmonary disease, whereas extrapulmonary symptoms and comorbidities may be systemic manifestations of these inflammatory processes, highlights an urgent need to discover novel, effective anti-inflammatory treatments for this disease. Some studies are suggesting that, by decreasing dynamic hyperinflation, bronchodilators might reduce systemic inflammation; inhaled corticosteroids and their combination with long-acting β2-agonists might contribute to this goal. Even so, the opinion that suppression of the inflammatory response might improve systemic complications is stimulating a search for novel anti-inflammatory therapies. Many drugs include those that inhibit the recruitment and activation of inflammatory cells and/or antagonise their products. However, many of these therapeutic strategies are not specific for neutrophilic inflammation because they affect other cell types, thus, it is difficult to interpret whether any clinical benefit observed is a result of a reduction in airway neutrophils. In any case, there is some evidence that drugs used to treat a co-morbid condition, such as statins, angiotensin converting enzyme (ACE) inhibitors and angiontensin II type 1 (AT1) receptor blockers as well as glycosaminoglycans and peroxisome proliferator-activated receptor (PPAR) agonists, might benefit chronic obstructive pulmonary disease patients because they deal with the extrapulmonary, systemic component of chronic obstructive pulmonary disease." @default.
- W2146656704 created "2016-06-24" @default.
- W2146656704 creator A5019120663 @default.
- W2146656704 creator A5054982987 @default.
- W2146656704 creator A5060089859 @default.
- W2146656704 creator A5062907116 @default.
- W2146656704 date "2007-10-01" @default.
- W2146656704 modified "2023-10-12" @default.
- W2146656704 title "Targeting systemic inflammation: novel therapies for the treatment of chronic obstructive pulmonary disease" @default.
- W2146656704 cites W1481234838 @default.
- W2146656704 cites W1508640815 @default.
- W2146656704 cites W1549228288 @default.
- W2146656704 cites W1591092186 @default.
- W2146656704 cites W1596920894 @default.
- W2146656704 cites W1652023268 @default.
- W2146656704 cites W1833512305 @default.
- W2146656704 cites W1855316965 @default.
- W2146656704 cites W1936156169 @default.
- W2146656704 cites W1968091752 @default.
- W2146656704 cites W1968998819 @default.
- W2146656704 cites W1972495472 @default.
- W2146656704 cites W1975914758 @default.
- W2146656704 cites W1976320491 @default.
- W2146656704 cites W1980767474 @default.
- W2146656704 cites W1984773197 @default.
- W2146656704 cites W1985496701 @default.
- W2146656704 cites W1986309205 @default.
- W2146656704 cites W1988481400 @default.
- W2146656704 cites W1988495571 @default.
- W2146656704 cites W1989954211 @default.
- W2146656704 cites W1991265445 @default.
- W2146656704 cites W1992021850 @default.
- W2146656704 cites W1992613976 @default.
- W2146656704 cites W1996136023 @default.
- W2146656704 cites W1996935852 @default.
- W2146656704 cites W1997062534 @default.
- W2146656704 cites W2001965102 @default.
- W2146656704 cites W2003578638 @default.
- W2146656704 cites W2003813387 @default.
- W2146656704 cites W2004030776 @default.
- W2146656704 cites W2004853207 @default.
- W2146656704 cites W2008639514 @default.
- W2146656704 cites W2010725414 @default.
- W2146656704 cites W2010800385 @default.
- W2146656704 cites W2013407710 @default.
- W2146656704 cites W2015491856 @default.
- W2146656704 cites W2017248535 @default.
- W2146656704 cites W2017460289 @default.
- W2146656704 cites W2021620212 @default.
- W2146656704 cites W2022727685 @default.
- W2146656704 cites W2023189425 @default.
- W2146656704 cites W2023865249 @default.
- W2146656704 cites W2027244023 @default.
- W2146656704 cites W2031907022 @default.
- W2146656704 cites W2034987812 @default.
- W2146656704 cites W2039911583 @default.
- W2146656704 cites W2041370237 @default.
- W2146656704 cites W2042242996 @default.
- W2146656704 cites W2043180355 @default.
- W2146656704 cites W2044490764 @default.
- W2146656704 cites W2045524724 @default.
- W2146656704 cites W2045749557 @default.
- W2146656704 cites W2046506812 @default.
- W2146656704 cites W2048895915 @default.
- W2146656704 cites W2049834479 @default.
- W2146656704 cites W2050359007 @default.
- W2146656704 cites W2058709767 @default.
- W2146656704 cites W2061867320 @default.
- W2146656704 cites W2063598450 @default.
- W2146656704 cites W2066010467 @default.
- W2146656704 cites W2067670378 @default.
- W2146656704 cites W2068274425 @default.
- W2146656704 cites W2071714347 @default.
- W2146656704 cites W2073468412 @default.
- W2146656704 cites W2073687825 @default.
- W2146656704 cites W2074251558 @default.
- W2146656704 cites W2075338976 @default.
- W2146656704 cites W2077156309 @default.
- W2146656704 cites W2077456873 @default.
- W2146656704 cites W2079843433 @default.
- W2146656704 cites W2080086845 @default.
- W2146656704 cites W2081130105 @default.
- W2146656704 cites W2081341003 @default.
- W2146656704 cites W2081906045 @default.
- W2146656704 cites W2085420819 @default.
- W2146656704 cites W2086789251 @default.
- W2146656704 cites W2087451614 @default.
- W2146656704 cites W2088136634 @default.
- W2146656704 cites W2090662888 @default.
- W2146656704 cites W2094203991 @default.
- W2146656704 cites W2097224246 @default.
- W2146656704 cites W2099424868 @default.
- W2146656704 cites W2103255778 @default.
- W2146656704 cites W2104068550 @default.
- W2146656704 cites W2104168490 @default.
- W2146656704 cites W2106579714 @default.
- W2146656704 cites W2106601190 @default.
- W2146656704 cites W2107555017 @default.