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- W2146659413 abstract "Thromboxane A2 (TxA2) and the activation of its receptor have been shown to modulate vasoconstriction and platelet aggregation as well as dopaminergic and serotonergic signalling. Dopaminergic and serotonergic systems play a crucial role in the pathophysiology of schizophrenia and these systems are the main targets of antipsychotics (APs). As the first antipsychotic (AP) chlorpromazine (CPZ) has already been shown to reduce TxA2, we hypothesized that the AP clozapine and its metabolite N-desmethylclozapine (NDMC) might also influence TxA2 production. Keywords: Chlorpromazine, clozapine, N-desmethylclozapine, thromboxane A2, thromboxane B2" @default.
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- W2146659413 date "2012-09-01" @default.
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- W2146659413 title "Impact of Clozapine, N-Desmethylclozapine and Chlorpromazine on Thromboxane Production in Vitro" @default.
- W2146659413 doi "https://doi.org/10.2174/1573406411208061032" @default.
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