Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146660215> ?p ?o ?g. }
- W2146660215 abstract "Accumulating evidence suggests a deleterious role for CD8+ T cells in multiple sclerosis (MS) pathogenesis. We have recently reported that hepatocyte growth factor (HGF), a potent neuroprotective factor, limits CD4+ T cell-mediated autoimmune neuroinflammation by promoting tolerogenic dendritic cells (DCs) and subsequently regulatory T cells. Whether HGF modulates cell-mediated immunity driven by MHC class I-restricted CD8+ T cells remains to be determined.Here we examined whether HGF regulates antigen-specific CD8+ T cell responses using an established model of murine cytotoxic T lymphocyte (CTL)-mediated killing.We found that HGF treatment of gp100-pulsed DCs reduced the activation of gp100-specific T cell receptor (Pmel-1) CD8+ T cells and subsequent MHC class I-restricted CTL-mediated cytolysis of gp100-pulsed target cells. The levels of perforin, granzyme B, IFN-γ, and the degranulation marker CD107a as well as Fas ligand were decreased among CD8+ T cells, suggestive of a dual inhibitory effect of HGF on the perforin/granzyme B- and Fas-based lytic pathways in cell-mediated cytotoxicity. Treatment of CD8+ T cells with concanamycin A, a potent inhibitor of the perforin-mediated cytotoxic pathway, abrogated CTL cytotoxicity indicating that blockade of the perforin-dependent killing is a major mechanism by which HGF diminished cytolysis of gp100-pulsed target cells. Moreover, HGF suppressed the generation of effector memory CTLs.Our findings indicate that HGF treatment limits both the generation and activity of effector CTL from naïve CD8+ T cells. Complementary to its impact on CD4+ T-cell CNS autoimmunity and myelin repair, our findings further suggest that HGF treatment could be exploited to control CD8+ T-cell-mediated, MHC I-restricted autoimmune dysfunctions such as MS." @default.
- W2146660215 created "2016-06-24" @default.
- W2146660215 creator A5032113324 @default.
- W2146660215 creator A5039822178 @default.
- W2146660215 creator A5040023354 @default.
- W2146660215 creator A5069718666 @default.
- W2146660215 creator A5081494961 @default.
- W2146660215 date "2013-12-01" @default.
- W2146660215 modified "2023-10-16" @default.
- W2146660215 title "The neurotrophic hepatocyte growth factor attenuates CD8+ cytotoxic T-lymphocyte activity" @default.
- W2146660215 cites W1497497385 @default.
- W2146660215 cites W1563129071 @default.
- W2146660215 cites W1769453339 @default.
- W2146660215 cites W1964885806 @default.
- W2146660215 cites W1990062483 @default.
- W2146660215 cites W1990840926 @default.
- W2146660215 cites W1991458644 @default.
- W2146660215 cites W1997578648 @default.
- W2146660215 cites W2005782838 @default.
- W2146660215 cites W2010003461 @default.
- W2146660215 cites W2010418081 @default.
- W2146660215 cites W2015911868 @default.
- W2146660215 cites W2019881908 @default.
- W2146660215 cites W2032124268 @default.
- W2146660215 cites W2037330887 @default.
- W2146660215 cites W2038735519 @default.
- W2146660215 cites W2039301743 @default.
- W2146660215 cites W2043683714 @default.
- W2146660215 cites W2064191046 @default.
- W2146660215 cites W2068932438 @default.
- W2146660215 cites W2072718666 @default.
- W2146660215 cites W2083873191 @default.
- W2146660215 cites W2085412596 @default.
- W2146660215 cites W2088345870 @default.
- W2146660215 cites W2091895188 @default.
- W2146660215 cites W2098772563 @default.
- W2146660215 cites W2099633268 @default.
- W2146660215 cites W2107642992 @default.
- W2146660215 cites W2120665673 @default.
- W2146660215 cites W2122209639 @default.
- W2146660215 cites W2130142616 @default.
- W2146660215 cites W2131851074 @default.
- W2146660215 cites W2133181143 @default.
- W2146660215 cites W2142767602 @default.
- W2146660215 cites W2142969867 @default.
- W2146660215 cites W2143742274 @default.
- W2146660215 cites W2165944571 @default.
- W2146660215 cites W2169366153 @default.
- W2146660215 cites W2170720046 @default.
- W2146660215 cites W2170761929 @default.
- W2146660215 cites W2172148458 @default.
- W2146660215 cites W2173694857 @default.
- W2146660215 cites W4236472486 @default.
- W2146660215 doi "https://doi.org/10.1186/1742-2094-10-154" @default.
- W2146660215 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3881506" @default.
- W2146660215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24344806" @default.
- W2146660215 hasPublicationYear "2013" @default.
- W2146660215 type Work @default.
- W2146660215 sameAs 2146660215 @default.
- W2146660215 citedByCount "24" @default.
- W2146660215 countsByYear W21466602152014 @default.
- W2146660215 countsByYear W21466602152015 @default.
- W2146660215 countsByYear W21466602152016 @default.
- W2146660215 countsByYear W21466602152017 @default.
- W2146660215 countsByYear W21466602152018 @default.
- W2146660215 countsByYear W21466602152019 @default.
- W2146660215 countsByYear W21466602152020 @default.
- W2146660215 countsByYear W21466602152021 @default.
- W2146660215 countsByYear W21466602152022 @default.
- W2146660215 countsByYear W21466602152023 @default.
- W2146660215 crossrefType "journal-article" @default.
- W2146660215 hasAuthorship W2146660215A5032113324 @default.
- W2146660215 hasAuthorship W2146660215A5039822178 @default.
- W2146660215 hasAuthorship W2146660215A5040023354 @default.
- W2146660215 hasAuthorship W2146660215A5069718666 @default.
- W2146660215 hasAuthorship W2146660215A5081494961 @default.
- W2146660215 hasBestOaLocation W21466602151 @default.
- W2146660215 hasConcept C129374314 @default.
- W2146660215 hasConcept C147483822 @default.
- W2146660215 hasConcept C147969180 @default.
- W2146660215 hasConcept C154317977 @default.
- W2146660215 hasConcept C167672396 @default.
- W2146660215 hasConcept C183193105 @default.
- W2146660215 hasConcept C190283241 @default.
- W2146660215 hasConcept C202751555 @default.
- W2146660215 hasConcept C203014093 @default.
- W2146660215 hasConcept C2776062744 @default.
- W2146660215 hasConcept C2776090121 @default.
- W2146660215 hasConcept C2780380082 @default.
- W2146660215 hasConcept C31573885 @default.
- W2146660215 hasConcept C502942594 @default.
- W2146660215 hasConcept C55493867 @default.
- W2146660215 hasConcept C66008609 @default.
- W2146660215 hasConcept C86803240 @default.
- W2146660215 hasConcept C8891405 @default.
- W2146660215 hasConcept C95444343 @default.
- W2146660215 hasConceptScore W2146660215C129374314 @default.
- W2146660215 hasConceptScore W2146660215C147483822 @default.
- W2146660215 hasConceptScore W2146660215C147969180 @default.
- W2146660215 hasConceptScore W2146660215C154317977 @default.