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• W2146673025 startingPage "1797" @default.
• W2146673025 abstract "Binding interactions between proteins and other molecules mediate numerous cellular processes, including metabolism, signaling, and regulation of gene expression. These interactions evolve in response to changes in the protein's chemical or physical environment (such as the addition of an antibiotic), or when genes duplicate and diverge. Several recent studies have shown the importance of folding stability in constraining protein evolution. Here we investigate how structural coupling between protein folding and binding -- the fact that most proteins can only bind their targets when folded -- gives rise to evolutionary coupling between the traits of folding stability and binding strength. Using biophysical and evolutionary modeling, we show how these protein traits can emerge as evolutionary spandrels even if they do not confer an intrinsic fitness advantage. In particular, proteins can evolve strong binding interactions that have no functional role but merely serve to stabilize the protein if misfolding is deleterious. Furthermore, such proteins may have divergent fates, evolving to bind or not bind their targets depending on random mutation events. These observations may explain the abundance of apparently nonfunctional interactions among proteins observed in high-throughput assays. In contrast, for proteins with both functional binding and deleterious misfolding, evolution may be highly predictable at the level of biophysical traits: adaptive paths are tightly constrained to first gain extra folding stability and then partially lose it as the new binding function is developed. These findings have important consequences for our understanding of fundamental evolutionary principles of both natural and engineered proteins." @default.
• W2146673025 created "2016-06-24" @default.
• W2146673025 creator A5056958220 @default.
• W2146673025 creator A5068312877 @default.
• W2146673025 date "2015-01-26" @default.
• W2146673025 modified "2023-09-25" @default.
• W2146673025 title "Protein folding and binding can emerge as evolutionary spandrels through structural coupling" @default.
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• W2146673025 doi "https://doi.org/10.1073/pnas.1415895112" @default.
• W2146673025 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4330747" @default.
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• W2146673025 hasPublicationYear "2015" @default.
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