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• W2146688768 abstract "Abstract This study was performed in order to establish whether selective depletion of serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the pigeon optic tectum (TeO) induced by p -chloroamphetamine ( p -CA) modified tectal evoked potentials (TEPs). TEPs in response to sinusoidal gratings of different contrast, spatial and temporal frequency were recorded in control pigeons and in pigeons intraperitoneally injected with p -CA (10 mg/kg; two administrations in consecutive days). TEPs of p -CA treated pigeons, as compared to those of control pigeons, were reduced in amplitude as a function of contrast, spatial and temporal frequency. In addition, TEPs of p -CA treated pigeons differed from those recorded in controls in their transfer characteristics of contrast and spatial frequency. In particular, TEPs of p -CA treated pigeons did not saturate at moderate contrast, unlike those of controls. Furthermore, the TEP spatial tuning in p -CA treated pigeons is broader than that in controls; it thus suggests a reduction of spatial-frequency selectivity. These findings indicate that a selective neurotoxin for serotonergic systems, such as p -CA, can serve as a useful denervation tool for the study of the serotonergic function in the pigeon TeO. In addition, selective changes of TEP properties suggest the possibility that serotonergic afferents play a modulatory role on the receptive-field characteristics of tectal neurons." @default.
• W2146688768 created "2016-06-24" @default.
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• W2146688768 date "1989-02-01" @default.
• W2146688768 modified "2023-09-26" @default.
• W2146688768 title "p-Chloroamphetamine treatment modifies evoked responses to sinusoidal gratings in the pigeon optic tectum" @default.
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• W2146688768 doi "https://doi.org/10.1017/s0952523800012001" @default.
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