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- W2146700627 abstract "‘The NCEP guidelines remain valid and appropriate LDL goals should still be attempted to be achieved. Statin therapy should remain the primary therapeutic intervention.’ The lipid hypothesis was originally proposed as a theory to explain the central role of dyslipidemia in the initiation and progression of atherosclerosis. The lipid hypothesis was supported by epidemiologic, pathologic and genetic observations. However, definitive proof of concept would require prospective clinical trial evidence that demonstrates that optimization of dyslipidemia would result in a reduction in risk from the complications of atherosclerosis. Epidemiologic studies that demonstrate a statistical correlation between dyslipidemia and atherosclerosis do not necessarily imply that pharmacologic modification of the lipid profile will alter the natural history of atherosclerosis. Early clinical trials that" @default.
- W2146700627 created "2016-06-24" @default.
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- W2146700627 date "2008-08-01" @default.
- W2146700627 modified "2023-09-27" @default.
- W2146700627 title "Clinical trials and surrogate end points: lessons from the ENHANCE trial" @default.
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- W2146700627 doi "https://doi.org/10.2217/17460875.3.4.353" @default.
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