FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146703091> ?p ?o ?g. }

• W2146703091 abstract "Pluripotent mouse embryonic stem cells (ESCs) are in vitro derivatives of the early mouse embryo. They can self-renew infinitely, and have the ability to differentiate into embryonic lineages including the germ line. ESCs have the ability to give rise to all tissues of a mouse if added early in embryogenesis. They possess a specific transcriptional network, an “open” chromatin state and a rapid cell cycle. Our research group is interested to study the link between cell fate determination and cell cycle regulation, using the Geminin protein as an anchor. Geminin plays a central role in controlling the fidelity of DNA replication, and more recently additional functions in the regulation of proteins involved in patterning and differentiation were recognized. It is highly expressed in the early embryo and in pluripotent cells, and its genetic inactivation is lethal after the first few cell divisions.We have generated ESCs, in which the Geminin gene can be inactivated by the addition of the small molecule tamoxifen. We found that Geminin is essential for self-renewal of pluripotent cells, and that the absence of Geminin causes reduction of pluripotency markers. The loss of Geminin altered the differentiation capacity of the ESCs; they could not give rise to the neural lineage anymore, but instead differentiated into the alternative mesendodermal lineage. Geminin turned out to be redundant in differentiated, somatic cells, but was necessary for their reprogramming to pluripotent cells. We could show that its function is targeted on the Sox2 gene, a key transcription factor of the pluripotency circuit, essential for the maintenance of pluripotency. The Sox2 enhancer requires Geminin for activity, and becomes epigenetically repressed in its absence. In conclusion, we introduce Geminin as a required factor for totipotency, pluripotency and the early neural lineage." @default.
• W2146703091 created "2016-06-24" @default.
• W2146703091 creator A5017168221 @default.
• W2146703091 date "2012-12-13" @default.
• W2146703091 modified "2023-09-27" @default.
• W2146703091 title "The Necessity of Geminin for Pluripotency and the Neural Lineage" @default.
• W2146703091 cites W109848799 @default.
• W2146703091 cites W1517950142 @default.
• W2146703091 cites W1608762409 @default.
• W2146703091 cites W1845629080 @default.
• W2146703091 cites W1885760911 @default.
• W2146703091 cites W1957763880 @default.
• W2146703091 cites W1965698498 @default.
• W2146703091 cites W1966758700 @default.
• W2146703091 cites W1967483776 @default.
• W2146703091 cites W1968042552 @default.
• W2146703091 cites W1968963646 @default.
• W2146703091 cites W1969015262 @default.
• W2146703091 cites W1974329353 @default.
• W2146703091 cites W1974365957 @default.
• W2146703091 cites W1974773432 @default.
• W2146703091 cites W1975200987 @default.
• W2146703091 cites W1976393793 @default.
• W2146703091 cites W1977135603 @default.
• W2146703091 cites W1980961600 @default.
• W2146703091 cites W1981088384 @default.
• W2146703091 cites W1981359686 @default.
• W2146703091 cites W1984052632 @default.
• W2146703091 cites W1985263934 @default.
• W2146703091 cites W1985608714 @default.
• W2146703091 cites W1987346667 @default.
• W2146703091 cites W1992160731 @default.
• W2146703091 cites W1993340233 @default.
• W2146703091 cites W1993611139 @default.
• W2146703091 cites W1994142477 @default.
• W2146703091 cites W1994144105 @default.
• W2146703091 cites W1995652309 @default.
• W2146703091 cites W1995955536 @default.
• W2146703091 cites W1996435746 @default.
• W2146703091 cites W2005437050 @default.
• W2146703091 cites W2006499356 @default.
• W2146703091 cites W2007028310 @default.
• W2146703091 cites W2007724923 @default.
• W2146703091 cites W2014385950 @default.
• W2146703091 cites W2015396326 @default.
• W2146703091 cites W2018193238 @default.
• W2146703091 cites W2018765068 @default.
• W2146703091 cites W2018855387 @default.
• W2146703091 cites W2021064677 @default.
• W2146703091 cites W2026273242 @default.
• W2146703091 cites W2029925140 @default.
• W2146703091 cites W2031496441 @default.
• W2146703091 cites W2033944657 @default.
• W2146703091 cites W2035467943 @default.
• W2146703091 cites W2038496974 @default.
• W2146703091 cites W2039543791 @default.
• W2146703091 cites W2040470603 @default.
• W2146703091 cites W2042742511 @default.
• W2146703091 cites W2043620174 @default.
• W2146703091 cites W2045665377 @default.
• W2146703091 cites W2045899482 @default.
• W2146703091 cites W2046922173 @default.
• W2146703091 cites W2051852464 @default.
• W2146703091 cites W2053911973 @default.
• W2146703091 cites W2054066197 @default.
• W2146703091 cites W2056665464 @default.
• W2146703091 cites W2057159461 @default.
• W2146703091 cites W2058414986 @default.
• W2146703091 cites W2060608189 @default.
• W2146703091 cites W2062118486 @default.
• W2146703091 cites W2064176848 @default.
• W2146703091 cites W2064450094 @default.
• W2146703091 cites W2068592712 @default.
• W2146703091 cites W2068780842 @default.
• W2146703091 cites W2069375339 @default.
• W2146703091 cites W2071241326 @default.
• W2146703091 cites W2072472133 @default.
• W2146703091 cites W2073815570 @default.
• W2146703091 cites W2078317565 @default.
• W2146703091 cites W2078430732 @default.
• W2146703091 cites W2088120691 @default.
• W2146703091 cites W2088182309 @default.
• W2146703091 cites W2090177259 @default.
• W2146703091 cites W2090260381 @default.
• W2146703091 cites W2095417588 @default.
• W2146703091 cites W2095491090 @default.
• W2146703091 cites W2096736856 @default.
• W2146703091 cites W2103790825 @default.
• W2146703091 cites W2107733431 @default.
• W2146703091 cites W2108244474 @default.
• W2146703091 cites W2109470020 @default.
• W2146703091 cites W2110381281 @default.
• W2146703091 cites W2110435536 @default.
• W2146703091 cites W2110803286 @default.
• W2146703091 cites W2111729634 @default.
• W2146703091 cites W2112156060 @default.
• W2146703091 cites W2113604152 @default.
• W2146703091 cites W2114161561 @default.
• W2146703091 cites W2115565539 @default.
• W2146703091 cites W2120199266 @default.

• next