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- W2146704530 abstract "Previous studies have suggested that the activity pattern of a cerebellar Purkinje cells (PC) is significantly controlled by voltage activated Ca2+ channels and Ca2+ activated K+ channels, present mainly on its elaborate dendritic tree [1]. Although the main somatic excitatory drive propagates very weakly into the dendritic tree [2], somehow a significant interaction between somatic and dendritic spiking occurs. Ca2+ entering through P-type channel is thought to be the main source of this excitability modulation, and this Ca2+ influx also activates large conductance (BK) and small conductance (SK) Ca2+ dependent K+ channels [1,3]. This interaction often results in the counter-intuitive computational somatic and dendritic spiking behavior of PCs [4], but nevertheless this important aspect has not been thoroughly investigated in previous computational modeling studies." @default.
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- W2146704530 date "2009-07-13" @default.
- W2146704530 modified "2023-09-25" @default.
- W2146704530 title "Modeling the excitability of the cerebellar Purkinje cell with detailed calcium dynamics" @default.
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- W2146704530 doi "https://doi.org/10.1186/1471-2202-10-s1-p34" @default.
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