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• W2146705514 abstract "Objective: To examine the recurrence of manifestations belonging to the spectrum of spondylarthropathy (SpA) in first-degree relatives of patients with SpA, and to estimate the recurrence risk ratio. Methods: Parents and siblings of consecutive SpA probands have been thoroughly investigated, including clinical data collection, pelvic x ray and human leukocyte antigen (HLA)-B27 status determination. The diagnosis of SpA was made according to European Spondylarthropathy Study Group and/or the Amor criteria. The recurrence risk ratio λ 1 , which gives an estimate of the weight of genetic factors, was calculated as the ratio of the recurrence risk of SpA in first-degree relatives compared with the population prevalence of SpA. The λ non-HLA was obtained by similar calculations restricted to HLA-B27+ individuals. Results: Most manifestations of SpA were more frequent among the 157 HLA-B27+ relatives of 83 probands than among their 111 HLA-B27- relatives. A diagnosis of SpA was made in 50 relatives of 31 (37%) probands. Recurrence was very similar between parents and siblings, without gender difference, resulting in overall recurrence risk of 12% in first-degree relatives and of 22.7% in HLA-B27+ relatives. The λ 1 value was 40 and the λ non-HLA value was 6.5, very close to the λ HLA value of 6.25 estimated from linkage study in SpA. Conclusions: A similar recurrence risk of SpA was observed between parents and siblings, consistent with a model of inheritance with no dominance variance and without sex influence. The weight of the non-HLA genetic component was equivalent to that estimated for the HLA locus, and fitted a model of multiplicative interaction between HLA and non-HLA genetic components." @default.
• W2146705514 created "2016-06-24" @default.
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• W2146705514 date "2008-04-15" @default.
• W2146705514 modified "2023-10-01" @default.
• W2146705514 title "Recurrence of spondylarthropathy among first-degree relatives of patients: a systematic cross-sectional study" @default.
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• W2146705514 doi "https://doi.org/10.1136/ard.2008.089599" @default.
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