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• W2146706051 abstract "Literature studies, 3D structure data, and a series of sequence analysis techniques were combined to reveal important residues in the structure and function of the ligand-binding domain of nuclear hormone receptors. A structure-based multiple sequence alignment allowed for the seamless combination of data from many different studies on different receptors into one single functional model. It was recently shown that a combined analysis of sequence entropy and variability can divide residues in five classes; (1) the main function or active site, (2) support for the main function, (3) signal transduction, (4) modulator or ligand binding and (5) the rest. Mutation data extracted from the literature and intermolecular contacts observed in nuclear receptor structures were analyzed in view of this classification and showed that the main function or active site residues of the nuclear receptor ligand-binding domain are involved in cofactor recruitment. Furthermore, the sequence entropy–variability analysis identified the presence of signal transduction residues that are located between the ligand, cofactor and dimer sites, suggesting communication between these regulatory binding sites. Experimental and computational results agreed well for most residues for which mutation data and intermolecular contact data were available. This allows us to predict the role of the residues for which no functional data is available yet. This study illustrates the power of family-based approaches towards the analysis of protein function, and it points out the problems and possibilities presented by the massive amounts of data that are becoming available in the “omics era”. The results shed light on the nuclear receptor family that is involved in processes ranging from cancer to infertility, and that is one of the more important targets in the pharmaceutical industry." @default.
• W2146706051 created "2016-06-24" @default.
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• W2146706051 date "2004-08-01" @default.
• W2146706051 modified "2023-10-16" @default.
• W2146706051 title "A Family-based Approach Reveals the Function of Residues in the Nuclear Receptor Ligand-binding Domain" @default.
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• W2146706051 cites W1774728382 @default.
• W2146706051 cites W1967784203 @default.
• W2146706051 cites W1970306476 @default.
• W2146706051 cites W1980222251 @default.
• W2146706051 cites W1981873124 @default.
• W2146706051 cites W1995924392 @default.
• W2146706051 cites W1996127793 @default.
• W2146706051 cites W1996832214 @default.
• W2146706051 cites W1998524704 @default.
• W2146706051 cites W2000468790 @default.
• W2146706051 cites W2000577172 @default.
• W2146706051 cites W2002032260 @default.
• W2146706051 cites W2004899821 @default.
• W2146706051 cites W2006046941 @default.
• W2146706051 cites W2006481713 @default.
• W2146706051 cites W2007450175 @default.
• W2146706051 cites W2013464914 @default.
• W2146706051 cites W2016014327 @default.
• W2146706051 cites W2017149825 @default.
• W2146706051 cites W2021534482 @default.
• W2146706051 cites W2026911129 @default.
• W2146706051 cites W2035416275 @default.
• W2146706051 cites W2040053707 @default.
• W2146706051 cites W2040074453 @default.
• W2146706051 cites W2042901562 @default.
• W2146706051 cites W2050842004 @default.
• W2146706051 cites W2052459433 @default.
• W2146706051 cites W2055878484 @default.
• W2146706051 cites W2060791849 @default.
• W2146706051 cites W2061357909 @default.
• W2146706051 cites W2064514012 @default.
• W2146706051 cites W2066122522 @default.
• W2146706051 cites W2067455153 @default.
• W2146706051 cites W2068063264 @default.
• W2146706051 cites W2074267393 @default.
• W2146706051 cites W2074370114 @default.
• W2146706051 cites W2076452736 @default.
• W2146706051 cites W2078707165 @default.
• W2146706051 cites W2083468430 @default.
• W2146706051 cites W2085124463 @default.
• W2146706051 cites W2085277871 @default.
• W2146706051 cites W2087151779 @default.
• W2146706051 cites W2090187735 @default.
• W2146706051 cites W2091169894 @default.
• W2146706051 cites W2093398099 @default.
• W2146706051 cites W2097762754 @default.
• W2146706051 cites W2101738855 @default.
• W2146706051 cites W2109539263 @default.
• W2146706051 cites W2111650618 @default.
• W2146706051 cites W2111778006 @default.
• W2146706051 cites W2111909811 @default.
• W2146706051 cites W2113456624 @default.
• W2146706051 cites W2119498937 @default.
• W2146706051 cites W2120372697 @default.
• W2146706051 cites W2124100109 @default.
• W2146706051 cites W2130479394 @default.
• W2146706051 cites W2132439221 @default.
• W2146706051 cites W2132717858 @default.
• W2146706051 cites W2133076404 @default.
• W2146706051 cites W2133978245 @default.
• W2146706051 cites W2137991504 @default.
• W2146706051 cites W2147596285 @default.
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• W2146706051 cites W2160534562 @default.
• W2146706051 cites W2162304802 @default.
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• W2146706051 doi "https://doi.org/10.1016/j.jmb.2004.05.075" @default.
• W2146706051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15276826" @default.
• W2146706051 hasPublicationYear "2004" @default.
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