Matches in SemOpenAlex for { <https://semopenalex.org/work/W214671435> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W214671435 endingPage "441" @default.
- W214671435 startingPage "431" @default.
- W214671435 abstract "To improve the knowledge of the very complex pathogenesis of acute pancreatitis, separated exocrine pancreatic cells were used as an experimental tool. Intact acinar cells were isolated from rat pancreas and the time course of their damage was studied in the presence of increasing activities of trypsin, chymotrypsin and, after, stepwise uncoupling of oxidative phosphorylation, by 2,4-dinitrophenol (DNP). With an increasing degree of uncoupling the half-life period of cells incubated was remarkably reduced. Extracellular trypsin, present in activities comparable with the endogenous trypsinogen content, was not effective in cell killing. Only when the trypsin activity was drastically enhanced was the rate of cell destruction accelerated. Compared with chymotrypsin, isolated acinar cells revealed some resistance to extracellular trypsin. But when the energy production was altered by partial uncoupling the susceptibility of these cells toward the action of trypsin was increased and their life time was remarkably reduced. The potentiation of the effects of trypsin and uncoupling on cell viability demonstrates the contribution of an intact energy metabolism to the protective potential of acinar cells against further noxae." @default.
- W214671435 created "2016-06-24" @default.
- W214671435 creator A5013678735 @default.
- W214671435 creator A5017939275 @default.
- W214671435 creator A5068677546 @default.
- W214671435 date "1989-05-01" @default.
- W214671435 modified "2023-10-17" @default.
- W214671435 title "Effects of trypsin, chymotrypsin, and uncoupling on survival of isolated acinar cells from rat pancreas" @default.
- W214671435 cites W100499925 @default.
- W214671435 cites W164441968 @default.
- W214671435 cites W2055186938 @default.
- W214671435 cites W2057354403 @default.
- W214671435 cites W2059146195 @default.
- W214671435 cites W2141090121 @default.
- W214671435 cites W2280503798 @default.
- W214671435 cites W2404366898 @default.
- W214671435 cites W2411789315 @default.
- W214671435 cites W2417148620 @default.
- W214671435 cites W2462376045 @default.
- W214671435 cites W26755721 @default.
- W214671435 cites W93946807 @default.
- W214671435 doi "https://doi.org/10.1007/bf02938478" @default.
- W214671435 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2732531" @default.
- W214671435 hasPublicationYear "1989" @default.
- W214671435 type Work @default.
- W214671435 sameAs 214671435 @default.
- W214671435 citedByCount "12" @default.
- W214671435 countsByYear W2146714352015 @default.
- W214671435 countsByYear W2146714352016 @default.
- W214671435 countsByYear W2146714352020 @default.
- W214671435 crossrefType "journal-article" @default.
- W214671435 hasAuthorship W214671435A5013678735 @default.
- W214671435 hasAuthorship W214671435A5017939275 @default.
- W214671435 hasAuthorship W214671435A5068677546 @default.
- W214671435 hasConcept C126322002 @default.
- W214671435 hasConcept C134018914 @default.
- W214671435 hasConcept C181199279 @default.
- W214671435 hasConcept C185592680 @default.
- W214671435 hasConcept C2775967933 @default.
- W214671435 hasConcept C2778401398 @default.
- W214671435 hasConcept C2778764654 @default.
- W214671435 hasConcept C2780340462 @default.
- W214671435 hasConcept C2781286802 @default.
- W214671435 hasConcept C28406088 @default.
- W214671435 hasConcept C2991930265 @default.
- W214671435 hasConcept C55493867 @default.
- W214671435 hasConcept C57600042 @default.
- W214671435 hasConcept C71924100 @default.
- W214671435 hasConcept C86803240 @default.
- W214671435 hasConceptScore W214671435C126322002 @default.
- W214671435 hasConceptScore W214671435C134018914 @default.
- W214671435 hasConceptScore W214671435C181199279 @default.
- W214671435 hasConceptScore W214671435C185592680 @default.
- W214671435 hasConceptScore W214671435C2775967933 @default.
- W214671435 hasConceptScore W214671435C2778401398 @default.
- W214671435 hasConceptScore W214671435C2778764654 @default.
- W214671435 hasConceptScore W214671435C2780340462 @default.
- W214671435 hasConceptScore W214671435C2781286802 @default.
- W214671435 hasConceptScore W214671435C28406088 @default.
- W214671435 hasConceptScore W214671435C2991930265 @default.
- W214671435 hasConceptScore W214671435C55493867 @default.
- W214671435 hasConceptScore W214671435C57600042 @default.
- W214671435 hasConceptScore W214671435C71924100 @default.
- W214671435 hasConceptScore W214671435C86803240 @default.
- W214671435 hasIssue "4" @default.
- W214671435 hasLocation W2146714351 @default.
- W214671435 hasLocation W2146714352 @default.
- W214671435 hasOpenAccess W214671435 @default.
- W214671435 hasPrimaryLocation W2146714351 @default.
- W214671435 hasRelatedWork W1543192799 @default.
- W214671435 hasRelatedWork W1672939180 @default.
- W214671435 hasRelatedWork W1990638012 @default.
- W214671435 hasRelatedWork W2055577277 @default.
- W214671435 hasRelatedWork W2058568838 @default.
- W214671435 hasRelatedWork W2075203190 @default.
- W214671435 hasRelatedWork W2080533976 @default.
- W214671435 hasRelatedWork W2115917445 @default.
- W214671435 hasRelatedWork W2168597484 @default.
- W214671435 hasRelatedWork W4211003552 @default.
- W214671435 hasVolume "4" @default.
- W214671435 isParatext "false" @default.
- W214671435 isRetracted "false" @default.
- W214671435 magId "214671435" @default.
- W214671435 workType "article" @default.