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- W2146720199 abstract "The human pathogen Aspergillus fumigatus adapts to stress encountered in the mammalian host as part of its ability to cause disease. The transcription factor SrbA plays a significant role in this process by regulating genes involved in hypoxia and low-iron adaptation, antifungal drug responses and virulence. SrbA is a direct transcriptional regulator of genes encoding key enzymes in the ergosterol biosynthesis pathway, including erg25A and erg25B, and ΔsrbA accumulates C4-methyl sterols, suggesting a loss of Erg25 activity [C4-sterol methyl oxidase (SMO)]. Characterization of the two genes encoding SMOs in Aspergillus fumigatus revealed that both serve as functional C4-demethylases, with Erg25A serving in a primary role, as Δerg25A accumulates more C4-methyl sterol intermediates than Δerg25B. Single deletion of these SMOs revealed alterations in canonical ergosterol biosynthesis, indicating that ergosterol may be produced in an alternative fashion in the absence of SMO activity. A Δerg25A strain displayed moderate susceptibility to hypoxia and the endoplasmic reticulum stress-inducing agent DTT, but was not required for virulence in murine or insect models of invasive aspergillosis. Inducing expression of erg25A partially restored the hypoxia growth defect of ΔsrbA. These findings implicated Aspergillus fumigatus SMOs in the maintenance of canonical ergosterol biosynthesis and indicated an overall involvement in the fungal stress response." @default.
- W2146720199 created "2016-06-24" @default.
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- W2146720199 creator A5077445259 @default.
- W2146720199 date "2014-11-01" @default.
- W2146720199 modified "2023-10-02" @default.
- W2146720199 title "Two C4-sterol methyl oxidases (Erg25) catalyse ergosterol intermediate demethylation and impact environmental stress adaptation in Aspergillus fumigatus" @default.
- W2146720199 cites W100151285 @default.
- W2146720199 cites W1530716380 @default.
- W2146720199 cites W1564374675 @default.
- W2146720199 cites W1878997932 @default.
- W2146720199 cites W1883743331 @default.
- W2146720199 cites W1909891465 @default.
- W2146720199 cites W1966884806 @default.
- W2146720199 cites W1967794782 @default.
- W2146720199 cites W1969365827 @default.
- W2146720199 cites W1973084729 @default.
- W2146720199 cites W1973867627 @default.
- W2146720199 cites W1980645672 @default.
- W2146720199 cites W1985009919 @default.
- W2146720199 cites W1985868031 @default.
- W2146720199 cites W1987640473 @default.
- W2146720199 cites W1988273601 @default.
- W2146720199 cites W1989091749 @default.
- W2146720199 cites W1991085977 @default.
- W2146720199 cites W1993223367 @default.
- W2146720199 cites W1994381407 @default.
- W2146720199 cites W1996168740 @default.
- W2146720199 cites W2000282782 @default.
- W2146720199 cites W2006472852 @default.
- W2146720199 cites W2007511762 @default.
- W2146720199 cites W2008342507 @default.
- W2146720199 cites W2010563194 @default.
- W2146720199 cites W2016551793 @default.
- W2146720199 cites W2017186637 @default.
- W2146720199 cites W2025959170 @default.
- W2146720199 cites W2032439358 @default.
- W2146720199 cites W2037851943 @default.
- W2146720199 cites W2038515531 @default.
- W2146720199 cites W2041843816 @default.
- W2146720199 cites W2044155734 @default.
- W2146720199 cites W2047195096 @default.
- W2146720199 cites W2050335832 @default.
- W2146720199 cites W2052648064 @default.
- W2146720199 cites W2057907550 @default.
- W2146720199 cites W2058042816 @default.
- W2146720199 cites W2068794749 @default.
- W2146720199 cites W2072284335 @default.
- W2146720199 cites W2073077939 @default.
- W2146720199 cites W2075407703 @default.
- W2146720199 cites W2075891899 @default.
- W2146720199 cites W2076168634 @default.
- W2146720199 cites W2078007825 @default.
- W2146720199 cites W2078167303 @default.
- W2146720199 cites W2079494420 @default.
- W2146720199 cites W2091915646 @default.
- W2146720199 cites W2098823719 @default.
- W2146720199 cites W2100624226 @default.
- W2146720199 cites W2108313755 @default.
- W2146720199 cites W2111022398 @default.
- W2146720199 cites W2120388340 @default.
- W2146720199 cites W2120725174 @default.
- W2146720199 cites W2124066457 @default.
- W2146720199 cites W2126268158 @default.
- W2146720199 cites W2126809009 @default.
- W2146720199 cites W2127366877 @default.
- W2146720199 cites W2131237274 @default.
- W2146720199 cites W2132546222 @default.
- W2146720199 cites W2139622987 @default.
- W2146720199 cites W2141434639 @default.
- W2146720199 cites W2144795145 @default.
- W2146720199 cites W2148735872 @default.
- W2146720199 cites W2153911335 @default.
- W2146720199 cites W2154425766 @default.
- W2146720199 cites W2158241162 @default.
- W2146720199 cites W2167785685 @default.
- W2146720199 cites W2170468557 @default.
- W2146720199 cites W2172067933 @default.
- W2146720199 cites W2266766322 @default.
- W2146720199 cites W2463924137 @default.
- W2146720199 cites W613316261 @default.
- W2146720199 doi "https://doi.org/10.1099/mic.0.080440-0" @default.
- W2146720199 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4219106" @default.
- W2146720199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25107308" @default.
- W2146720199 hasPublicationYear "2014" @default.
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