FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146725851> ?p ?o ?g. }

• W2146725851 abstract "During the last two decades progress in the genetics of aging in invertebrate models such as C. elegans and D. melanogaster has clearly demonstrated the existence of regulatory pathways that control the rate of aging in these organisms, such as the insulin-like pathway, the Jun kinase pathway and the Sir2 deacetylase pathway. Moreover, it was rapidly shown that some of these pathways are conserved from yeast to humans. In parallel to genetic studies, genomic expression approaches have given us significant information on the gene expression modifications that occur during aging either in wild type or long-lived mutant animals. But most of the genomic studies of invertebrate models have been performed so far on whole animals, while several recent studies in mammals have shown that the effects of aging are tissue specific.We used oligonucleotide microarrays to address the specificities of transcriptional responses in aging Drosophila in head, thorax or whole body. These fly parts are enriched in transcripts that represent different and complementary sets of genes. We present evidence for both specific and common transcriptional responses during the aging process in these tissues. About half of the genes described as downregulated with age are linked to reproduction and enriched in gonads. Greater downregulation of mitochondrial genes, activation of the JNK pathway and upregulation of proteasome subunits in the thorax of aged flies all suggest that muscle may be particularly sensitive to aging. Simultaneous age-related impairment of synaptic transmission gene expression is observed in fly heads. In addition, a detailed comparison with other microarray data indicates that in aged flies there are significant deviations from the canonical responses to oxidative stress and immune stress.Our data demonstrates the advantages and value of regionalized and comparative analysis of gene expression in aging animals. Adding to the age-regulated genes already identified in whole animal studies, it provides lists of new regionalized genes to be studied for their functional role in the aging process. This work also emphasizes the need for such experiments to reveal in greater detail the consequences of the transcriptional modifications induced by aging regulatory pathways." @default.
• W2146725851 created "2016-06-24" @default.
• W2146725851 creator A5046580490 @default.
• W2146725851 creator A5058497920 @default.
• W2146725851 creator A5062742665 @default.
• W2146725851 creator A5086535580 @default.
• W2146725851 date "2006-04-04" @default.
• W2146725851 modified "2023-10-18" @default.
• W2146725851 title "Specific age related signatures in Drosophila body parts transcriptome" @default.
• W2146725851 cites W1486595217 @default.
• W2146725851 cites W1488124756 @default.
• W2146725851 cites W1535452588 @default.
• W2146725851 cites W1754711307 @default.
• W2146725851 cites W1812816875 @default.
• W2146725851 cites W1841140288 @default.
• W2146725851 cites W1967181393 @default.
• W2146725851 cites W1967233398 @default.
• W2146725851 cites W1970026878 @default.
• W2146725851 cites W1972317763 @default.
• W2146725851 cites W1979212686 @default.
• W2146725851 cites W1993504110 @default.
• W2146725851 cites W1993957633 @default.
• W2146725851 cites W1999312292 @default.
• W2146725851 cites W2002097809 @default.
• W2146725851 cites W2004127615 @default.
• W2146725851 cites W2017147713 @default.
• W2146725851 cites W2034734284 @default.
• W2146725851 cites W2040863926 @default.
• W2146725851 cites W2044917509 @default.
• W2146725851 cites W2047683380 @default.
• W2146725851 cites W2053685560 @default.
• W2146725851 cites W2056388945 @default.
• W2146725851 cites W2058737138 @default.
• W2146725851 cites W2062048451 @default.
• W2146725851 cites W2073151196 @default.
• W2146725851 cites W2083416570 @default.
• W2146725851 cites W2087242804 @default.
• W2146725851 cites W2091613063 @default.
• W2146725851 cites W2097904015 @default.
• W2146725851 cites W2100831836 @default.
• W2146725851 cites W2103268140 @default.
• W2146725851 cites W2107900138 @default.
• W2146725851 cites W2109972881 @default.
• W2146725851 cites W2112845079 @default.
• W2146725851 cites W2113374835 @default.
• W2146725851 cites W2116634113 @default.
• W2146725851 cites W2118852675 @default.
• W2146725851 cites W2120317882 @default.
• W2146725851 cites W2124959176 @default.
• W2146725851 cites W2129128106 @default.
• W2146725851 cites W2130198725 @default.
• W2146725851 cites W2132103131 @default.
• W2146725851 cites W2137068591 @default.
• W2146725851 cites W2137961859 @default.
• W2146725851 cites W2142842603 @default.
• W2146725851 cites W2155265427 @default.
• W2146725851 cites W2157795344 @default.
• W2146725851 cites W2160697532 @default.
• W2146725851 cites W2166146113 @default.
• W2146725851 cites W2170138349 @default.
• W2146725851 cites W4294107304 @default.
• W2146725851 doi "https://doi.org/10.1186/1471-2164-7-69" @default.
• W2146725851 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1481561" @default.
• W2146725851 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16584578" @default.
• W2146725851 hasPublicationYear "2006" @default.
• W2146725851 type Work @default.
• W2146725851 sameAs 2146725851 @default.
• W2146725851 citedByCount "97" @default.
• W2146725851 countsByYear W21467258512012 @default.
• W2146725851 countsByYear W21467258512013 @default.
• W2146725851 countsByYear W21467258512014 @default.
• W2146725851 countsByYear W21467258512015 @default.
• W2146725851 countsByYear W21467258512016 @default.
• W2146725851 countsByYear W21467258512017 @default.
• W2146725851 countsByYear W21467258512018 @default.
• W2146725851 countsByYear W21467258512019 @default.
• W2146725851 countsByYear W21467258512020 @default.
• W2146725851 countsByYear W21467258512022 @default.
• W2146725851 countsByYear W21467258512023 @default.
• W2146725851 crossrefType "journal-article" @default.
• W2146725851 hasAuthorship W2146725851A5046580490 @default.
• W2146725851 hasAuthorship W2146725851A5058497920 @default.
• W2146725851 hasAuthorship W2146725851A5062742665 @default.
• W2146725851 hasAuthorship W2146725851A5086535580 @default.
• W2146725851 hasBestOaLocation W21467258511 @default.
• W2146725851 hasConcept C104317684 @default.
• W2146725851 hasConcept C127561419 @default.
• W2146725851 hasConcept C150194340 @default.
• W2146725851 hasConcept C162317418 @default.
• W2146725851 hasConcept C18431079 @default.
• W2146725851 hasConcept C186836561 @default.
• W2146725851 hasConcept C19843653 @default.
• W2146725851 hasConcept C2780104201 @default.
• W2146725851 hasConcept C54355233 @default.
• W2146725851 hasConcept C8415881 @default.
• W2146725851 hasConcept C86803240 @default.
• W2146725851 hasConcept C95371953 @default.
• W2146725851 hasConcept C95444343 @default.
• W2146725851 hasConceptScore W2146725851C104317684 @default.
• W2146725851 hasConceptScore W2146725851C127561419 @default.

• next