FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146737231> ?p ?o ?g. }

• W2146737231 abstract "SKF83959 stimulates the phospholipase Cβ/inositol phosphate 3 pathway, resulting in the activation of Ca2+/calmodulin-dependent kinase IIα, which affects the synthesis of brain-derived neurotrophic factor, a neurotrophic factor critical for the pathophysiology of depression. Previous reports showed that SKF83959 elicited antidepressant activity in the forced swim test and tail suspension test as a novel triple reuptake inhibitor. However, there are no studies showing the effects of SKF83959 in a chronic stress model of depression and the role of phospholipase C/inositol phosphate 3/calmodulin-dependent kinase IIα/brain-derived neurotrophic factor pathway in SKF83959-mediated antidepressant effects. In this study, SKF83959 was firstly investigated in the chronic social defeat stress model of depression. The changes in hippocampal neurogenesis, dendrite spine density, and brain-derived neurotrophic factor signaling pathway after chronic social defeat stress and SKF83959 treatment were then investigated. Pharmacological inhibitors and small interfering RNA/short hairpin RNA methods were further used to explore the antidepressive mechanisms of SKF83959. We found that SKF83959 produced antidepressant effects in the chronic social defeat stress model and also restored the chronic social defeat stress-induced decrease in hippocampal brain-derived neurotrophic factor signaling pathway, dendritic spine density, and neurogenesis. By using various inhibitors and siRNA/shRNA methods, we further demonstrated that the hippocampal dopamine D5 receptor, phospholipase C/inositol phosphate 3/ calmodulin-dependent kinase IIα pathway, and brain-derived neurotrophic factor system are all necessary for the SKF83959 effects. These results suggest that SKF83959 can be developed as a novel antidepressant and produces antidepressant effects via the hippocampal D5/ phospholipase C/inositol phosphate 3/calmodulin-dependent kinase IIα/brain-derived neurotrophic factor pathway." @default.
• W2146737231 created "2016-06-24" @default.
• W2146737231 creator A5001382985 @default.
• W2146737231 creator A5002661071 @default.
• W2146737231 creator A5010140052 @default.
• W2146737231 creator A5014928422 @default.
• W2146737231 creator A5031540971 @default.
• W2146737231 creator A5031734082 @default.
• W2146737231 creator A5069429055 @default.
• W2146737231 creator A5088476571 @default.
• W2146737231 date "2015-01-31" @default.
• W2146737231 modified "2023-10-02" @default.
• W2146737231 title "SKF83959 Produces Antidepressant Effects in a Chronic Social Defeat Stress Model of Depression through BDNF-TrkB Pathway" @default.
• W2146737231 cites W1536787393 @default.
• W2146737231 cites W1671833268 @default.
• W2146737231 cites W1950744654 @default.
• W2146737231 cites W1967017538 @default.
• W2146737231 cites W1972010974 @default.
• W2146737231 cites W1972449722 @default.
• W2146737231 cites W1975445596 @default.
• W2146737231 cites W1977133761 @default.
• W2146737231 cites W1981654563 @default.
• W2146737231 cites W1982313674 @default.
• W2146737231 cites W1983295831 @default.
• W2146737231 cites W1983535614 @default.
• W2146737231 cites W1987604172 @default.
• W2146737231 cites W1987867146 @default.
• W2146737231 cites W2002669733 @default.
• W2146737231 cites W2003982930 @default.
• W2146737231 cites W2005698684 @default.
• W2146737231 cites W2029492990 @default.
• W2146737231 cites W2034497459 @default.
• W2146737231 cites W2039482493 @default.
• W2146737231 cites W2047961162 @default.
• W2146737231 cites W2048702728 @default.
• W2146737231 cites W2053476648 @default.
• W2146737231 cites W2068501956 @default.
• W2146737231 cites W2071793091 @default.
• W2146737231 cites W2075762292 @default.
• W2146737231 cites W2077727405 @default.
• W2146737231 cites W2086909723 @default.
• W2146737231 cites W2088050000 @default.
• W2146737231 cites W2089198034 @default.
• W2146737231 cites W2089351762 @default.
• W2146737231 cites W2089394861 @default.
• W2146737231 cites W2092015384 @default.
• W2146737231 cites W2094870622 @default.
• W2146737231 cites W2097275043 @default.
• W2146737231 cites W2104419734 @default.
• W2146737231 cites W2108730203 @default.
• W2146737231 cites W2113723602 @default.
• W2146737231 cites W2121651624 @default.
• W2146737231 cites W2132334517 @default.
• W2146737231 cites W2133565799 @default.
• W2146737231 cites W2134083528 @default.
• W2146737231 cites W2137385309 @default.
• W2146737231 cites W2140178312 @default.
• W2146737231 cites W2146517666 @default.
• W2146737231 cites W2148239264 @default.
• W2146737231 cites W2168699664 @default.
• W2146737231 cites W2168950597 @default.
• W2146737231 cites W2181560023 @default.
• W2146737231 cites W2282636056 @default.
• W2146737231 cites W2407887454 @default.
• W2146737231 doi "https://doi.org/10.1093/ijnp/pyu096" @default.
• W2146737231 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4438541" @default.
• W2146737231 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25522427" @default.
• W2146737231 hasPublicationYear "2015" @default.
• W2146737231 type Work @default.
• W2146737231 sameAs 2146737231 @default.
• W2146737231 citedByCount "36" @default.
• W2146737231 countsByYear W21467372312015 @default.
• W2146737231 countsByYear W21467372312016 @default.
• W2146737231 countsByYear W21467372312017 @default.
• W2146737231 countsByYear W21467372312018 @default.
• W2146737231 countsByYear W21467372312019 @default.
• W2146737231 countsByYear W21467372312020 @default.
• W2146737231 countsByYear W21467372312021 @default.
• W2146737231 countsByYear W21467372312022 @default.
• W2146737231 countsByYear W21467372312023 @default.
• W2146737231 crossrefType "journal-article" @default.
• W2146737231 hasAuthorship W2146737231A5001382985 @default.
• W2146737231 hasAuthorship W2146737231A5002661071 @default.
• W2146737231 hasAuthorship W2146737231A5010140052 @default.
• W2146737231 hasAuthorship W2146737231A5014928422 @default.
• W2146737231 hasAuthorship W2146737231A5031540971 @default.
• W2146737231 hasAuthorship W2146737231A5031734082 @default.
• W2146737231 hasAuthorship W2146737231A5069429055 @default.
• W2146737231 hasAuthorship W2146737231A5088476571 @default.
• W2146737231 hasBestOaLocation W21467372312 @default.
• W2146737231 hasConcept C126322002 @default.
• W2146737231 hasConcept C134018914 @default.
• W2146737231 hasConcept C136569192 @default.
• W2146737231 hasConcept C15744967 @default.
• W2146737231 hasConcept C160539049 @default.
• W2146737231 hasConcept C169760540 @default.
• W2146737231 hasConcept C170493617 @default.
• W2146737231 hasConcept C2778654844 @default.
• W2146737231 hasConcept C2778790584 @default.
• W2146737231 hasConcept C2779177272 @default.

• next