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• W2146755737 abstract "Plants may serve as superior production systems for complex recombinant pharmaceuticals. Current strategies for improving plant-based systems include the development of large-scale production facilities as well as the optimisation of protein modifications. While post-translational modifications of plant proteins generally resemble those of mammalian proteins, certain plant-specific protein-linked sugars are immunogenic in humans, a fact that restricts the use of plants in biopharmaceutical production so far. The moss Physcomitrella patens was developed as a contained tissue culture system for recombinant protein production in photo-bioreactors. By targeted gene replacements, moss strains were created with non-immunogenic humanised glycan patterns. These were proven to be superior to currently used mammalian cell lines in producing antibodies with enhanced effectiveness." @default.
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• W2146755737 date "2007-10-01" @default.
• W2146755737 modified "2023-10-14" @default.
• W2146755737 title "Moss bioreactors producing improved biopharmaceuticals" @default.
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• W2146755737 doi "https://doi.org/10.1016/j.copbio.2007.07.012" @default.
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