FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146758511> ?p ?o ?g. }

• W2146758511 endingPage "1579" @default.
• W2146758511 startingPage "1569" @default.
• W2146758511 abstract "SPARC (secreted protein acidic and rich in cysteine)/BM 40/osteonectin is a matricellular protein shown to function as a counteradhesive factor that induces cell rounding and as an inhibitor of cell proliferation. These activities have been defined in cell culture, in which interpretation has been complicated by the presence of endogenous SPARC. We therefore sought to determine whether cell shape and proliferation would be affected by the absence of SPARC. Mesangial cells, fibroblasts, and aortic smooth muscle cells were isolated from SPARC-null and age-matched, wild-type mice. In contrast to wild-type cells, SPARC-null mesangial cells exhibited a flat morphology and an altered actin cytoskeleton. In addition, vinculin-containing focal adhesions were distributed over the center of SPARC-null cells, whereas in wild-type cells, the number of focal adhesions was reduced, and these structures were restricted largely to the cell periphery. Although the SPARC-null fibroblasts did not display overt differences in cell morphology, the cells responded to exogenous recombinant SPARC by rounding up in a manner similar to that of wild-type fibroblasts. Thus, the expression of endogenous SPARC is not required for the response of cells to SPARC. Additionally, SPARC-null mesangial cells, fibroblasts, and smooth muscle cells proliferated faster than their respective wild-type counterparts. Null cells also showed a greater sensitivity to the inhibition of cell cycle progression by the addition of recombinant SPARC. The increased proliferation rate of SPARC-null cells appeared to be mediated, at least in part, by an increase in the cell cycle regulatory protein cyclin A. We conclude that the expression of SPARC influences the cellular architecture of mesangial cells and that SPARC plays a role in the regulation of cell cycle in mesangial cells, fibroblasts, and smooth muscle cells." @default.
• W2146758511 created "2016-06-24" @default.
• W2146758511 creator A5002256474 @default.
• W2146758511 creator A5007993807 @default.
• W2146758511 creator A5019134227 @default.
• W2146758511 creator A5038364145 @default.
• W2146758511 creator A5062207203 @default.
• W2146758511 date "1999-05-01" @default.
• W2146758511 modified "2023-09-23" @default.
• W2146758511 title "Primary Mesenchymal Cells Isolated from SPARC-null Mice Exhibit Altered Morphology and Rates of Proliferation" @default.
• W2146758511 cites W118156260 @default.
• W2146758511 cites W1516994555 @default.
• W2146758511 cites W1606319577 @default.
• W2146758511 cites W1979478786 @default.
• W2146758511 cites W1981271183 @default.
• W2146758511 cites W1989859149 @default.
• W2146758511 cites W1995425542 @default.
• W2146758511 cites W1996904214 @default.
• W2146758511 cites W2001362512 @default.
• W2146758511 cites W2003937770 @default.
• W2146758511 cites W2008757399 @default.
• W2146758511 cites W2018289835 @default.
• W2146758511 cites W2018504080 @default.
• W2146758511 cites W2026274081 @default.
• W2146758511 cites W2026522676 @default.
• W2146758511 cites W2028691987 @default.
• W2146758511 cites W2029723738 @default.
• W2146758511 cites W2054118339 @default.
• W2146758511 cites W2056829959 @default.
• W2146758511 cites W2060045581 @default.
• W2146758511 cites W2060285807 @default.
• W2146758511 cites W2084392563 @default.
• W2146758511 cites W2100837269 @default.
• W2146758511 cites W2105307395 @default.
• W2146758511 cites W2108736751 @default.
• W2146758511 cites W2127186381 @default.
• W2146758511 cites W2165030170 @default.
• W2146758511 cites W2415994997 @default.
• W2146758511 cites W259476979 @default.
• W2146758511 cites W4245637755 @default.
• W2146758511 doi "https://doi.org/10.1091/mbc.10.5.1569" @default.
• W2146758511 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/25344" @default.
• W2146758511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10233163" @default.
• W2146758511 hasPublicationYear "1999" @default.
• W2146758511 type Work @default.
• W2146758511 sameAs 2146758511 @default.
• W2146758511 citedByCount "87" @default.
• W2146758511 countsByYear W21467585112012 @default.
• W2146758511 countsByYear W21467585112013 @default.
• W2146758511 countsByYear W21467585112014 @default.
• W2146758511 countsByYear W21467585112015 @default.
• W2146758511 countsByYear W21467585112016 @default.
• W2146758511 countsByYear W21467585112019 @default.
• W2146758511 countsByYear W21467585112020 @default.
• W2146758511 countsByYear W21467585112022 @default.
• W2146758511 crossrefType "journal-article" @default.
• W2146758511 hasAuthorship W2146758511A5002256474 @default.
• W2146758511 hasAuthorship W2146758511A5007993807 @default.
• W2146758511 hasAuthorship W2146758511A5019134227 @default.
• W2146758511 hasAuthorship W2146758511A5038364145 @default.
• W2146758511 hasAuthorship W2146758511A5062207203 @default.
• W2146758511 hasBestOaLocation W21467585112 @default.
• W2146758511 hasConcept C121853132 @default.
• W2146758511 hasConcept C125705527 @default.
• W2146758511 hasConcept C131075544 @default.
• W2146758511 hasConcept C1491633281 @default.
• W2146758511 hasConcept C151166631 @default.
• W2146758511 hasConcept C153911025 @default.
• W2146758511 hasConcept C160160445 @default.
• W2146758511 hasConcept C181199279 @default.
• W2146758511 hasConcept C189014844 @default.
• W2146758511 hasConcept C189165786 @default.
• W2146758511 hasConcept C2775893135 @default.
• W2146758511 hasConcept C2777979848 @default.
• W2146758511 hasConcept C2781460891 @default.
• W2146758511 hasConcept C54355233 @default.
• W2146758511 hasConcept C55493867 @default.
• W2146758511 hasConcept C62112901 @default.
• W2146758511 hasConcept C62478195 @default.
• W2146758511 hasConcept C81885089 @default.
• W2146758511 hasConcept C86803240 @default.
• W2146758511 hasConcept C95444343 @default.
• W2146758511 hasConceptScore W2146758511C121853132 @default.
• W2146758511 hasConceptScore W2146758511C125705527 @default.
• W2146758511 hasConceptScore W2146758511C131075544 @default.
• W2146758511 hasConceptScore W2146758511C1491633281 @default.
• W2146758511 hasConceptScore W2146758511C151166631 @default.
• W2146758511 hasConceptScore W2146758511C153911025 @default.
• W2146758511 hasConceptScore W2146758511C160160445 @default.
• W2146758511 hasConceptScore W2146758511C181199279 @default.
• W2146758511 hasConceptScore W2146758511C189014844 @default.
• W2146758511 hasConceptScore W2146758511C189165786 @default.
• W2146758511 hasConceptScore W2146758511C2775893135 @default.
• W2146758511 hasConceptScore W2146758511C2777979848 @default.
• W2146758511 hasConceptScore W2146758511C2781460891 @default.
• W2146758511 hasConceptScore W2146758511C54355233 @default.
• W2146758511 hasConceptScore W2146758511C55493867 @default.
• W2146758511 hasConceptScore W2146758511C62112901 @default.

• next