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- W2146761569 endingPage "277" @default.
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- W2146761569 abstract "Multiple myeloma (MM) is the second most common hematological malignancy and is characterized by the aberrant proliferation of terminally differentiated plasma B cells with impairment in apoptosis capacity. Particularly, osteolytic bone diseases and renal failure resulting from hyperparaproteinemia and hypercalcemia have been the major serious sequelae that are inextricably linked with MM tumor progression. Despite the introduction of new treatment regimens, problematic neuropathy, thrombocytopenia, drug resistance and high MM relapse rates continue to plague the current therapies. New chemical agents are in development on the basis of understanding several signaling pathways and molecular mechanisms like tumor necrosis factor-α, proteasome, PI3K and MARKs. This review focuses on the most recent patents and clinical trials in the development of new medicine for the treatment of multiple myeloma. Furthermore, the important signaling pathways involved in the proliferation, survival and apoptosis of myeloma cells will be discussed." @default.
- W2146761569 created "2016-06-24" @default.
- W2146761569 creator A5001167858 @default.
- W2146761569 creator A5002958802 @default.
- W2146761569 creator A5007520743 @default.
- W2146761569 creator A5053632028 @default.
- W2146761569 date "2014-05-01" @default.
- W2146761569 modified "2023-09-27" @default.
- W2146761569 title "Recent advances in antimultiple myeloma drug development" @default.
- W2146761569 cites W130016783 @default.
- W2146761569 cites W1486196586 @default.
- W2146761569 cites W1545865598 @default.
- W2146761569 cites W1583671024 @default.
- W2146761569 cites W163040189 @default.
- W2146761569 cites W1654790906 @default.
- W2146761569 cites W1759028523 @default.
- W2146761569 cites W1761234319 @default.
- W2146761569 cites W1810265271 @default.
- W2146761569 cites W1944909911 @default.
- W2146761569 cites W1964334216 @default.
- W2146761569 cites W1965492236 @default.
- W2146761569 cites W1966308718 @default.
- W2146761569 cites W1966704794 @default.
- W2146761569 cites W1970433764 @default.
- W2146761569 cites W1972201331 @default.
- W2146761569 cites W1977348505 @default.
- W2146761569 cites W1978991749 @default.
- W2146761569 cites W1983074899 @default.
- W2146761569 cites W1995092890 @default.
- W2146761569 cites W1998854709 @default.
- W2146761569 cites W1998881647 @default.
- W2146761569 cites W2001310748 @default.
- W2146761569 cites W2001924054 @default.
- W2146761569 cites W2004794222 @default.
- W2146761569 cites W2009140393 @default.
- W2146761569 cites W2010184965 @default.
- W2146761569 cites W2011387568 @default.
- W2146761569 cites W2013187395 @default.
- W2146761569 cites W2015577159 @default.
- W2146761569 cites W2029047196 @default.
- W2146761569 cites W2033430437 @default.
- W2146761569 cites W2037834319 @default.
- W2146761569 cites W2039196526 @default.
- W2146761569 cites W2039215669 @default.
- W2146761569 cites W2040859980 @default.
- W2146761569 cites W2044227662 @default.
- W2146761569 cites W2046087708 @default.
- W2146761569 cites W2049262651 @default.
- W2146761569 cites W2049990925 @default.
- W2146761569 cites W2051372009 @default.
- W2146761569 cites W2052603677 @default.
- W2146761569 cites W2052763184 @default.
- W2146761569 cites W2052927123 @default.
- W2146761569 cites W2058468326 @default.
- W2146761569 cites W2062352386 @default.
- W2146761569 cites W2063355387 @default.
- W2146761569 cites W2067653691 @default.
- W2146761569 cites W2071989867 @default.
- W2146761569 cites W2072645819 @default.
- W2146761569 cites W2073363483 @default.
- W2146761569 cites W2073944708 @default.
- W2146761569 cites W2074174622 @default.
- W2146761569 cites W2075131681 @default.
- W2146761569 cites W2075262248 @default.
- W2146761569 cites W2084416720 @default.
- W2146761569 cites W2085793397 @default.
- W2146761569 cites W2086061986 @default.
- W2146761569 cites W2086808745 @default.
- W2146761569 cites W2086990334 @default.
- W2146761569 cites W2088123597 @default.
- W2146761569 cites W2089311432 @default.
- W2146761569 cites W2089465877 @default.
- W2146761569 cites W2091774189 @default.
- W2146761569 cites W2095026025 @default.
- W2146761569 cites W2096844711 @default.
- W2146761569 cites W2098370110 @default.
- W2146761569 cites W2099510363 @default.
- W2146761569 cites W2100945326 @default.
- W2146761569 cites W2102401722 @default.
- W2146761569 cites W2102725664 @default.
- W2146761569 cites W2104928407 @default.
- W2146761569 cites W2106838577 @default.
- W2146761569 cites W2108353976 @default.
- W2146761569 cites W2109371953 @default.
- W2146761569 cites W2109606035 @default.
- W2146761569 cites W2109635468 @default.
- W2146761569 cites W2113472355 @default.
- W2146761569 cites W2114351320 @default.
- W2146761569 cites W2116619860 @default.
- W2146761569 cites W2124343538 @default.
- W2146761569 cites W2124618015 @default.
- W2146761569 cites W2127909824 @default.
- W2146761569 cites W2132160266 @default.
- W2146761569 cites W2133739087 @default.
- W2146761569 cites W2133970943 @default.
- W2146761569 cites W2135481148 @default.
- W2146761569 cites W2141502099 @default.
- W2146761569 cites W2142845200 @default.