FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146775666> ?p ?o ?g. }

• W2146775666 endingPage "L713" @default.
• W2146775666 startingPage "L705" @default.
• W2146775666 abstract "Recent studies revealed an importance of a monomeric GTP-binding protein, RhoA, in contraction of bronchial smooth muscle (BSM). RhoA and its downstream have been proposed as a new target for the treatment of airway hyperresponsiveness in asthma. Statins are known to inhibit the functional activation of RhoA via the depletion of geranylgeranylpyrophosphate. To determine the beneficial effects of statins on the airway hyperresponsiveness in allergic bronchial asthma, we investigated the effects of systemic treatment with lovastatin on the augmented BSM contraction and activation of RhoA in rats with allergic bronchial asthma. Rats were sensitized and repeatedly challenged with 2,4-dinitrophenylated Ascaris suum antigen. Animals were also treated with lovastatin (4 mg kg(-1) day(-1) ip) once a day before and during the antigen inhalation period. Repeated antigen inhalation caused a marked BSM hyperresponsiveness to ACh with the increased expression and translocation of RhoA. Lovastatin treatments significantly attenuated both the augmented contraction and RhoA translocation to the plasma membrane. Lovastatin also reduced the increased cell number in bronchoalveolar lavage fluids and histological changes induced by antigen exposure, whereas the levels of immunoglobulin E in sera and interleukins-4, -6, and -13 in bronchoalveolar lavage fluids were not significantly changed. These findings suggest that lovastatin ameliorates antigen-induced BSM hyperresponsiveness, an important factor of airway hyperresponsiveness in allergic asthmatics, probably by reducing the RhoA-mediated signaling." @default.
• W2146775666 created "2016-06-24" @default.
• W2146775666 creator A5002276017 @default.
• W2146775666 creator A5004477338 @default.
• W2146775666 creator A5021925277 @default.
• W2146775666 creator A5058666311 @default.
• W2146775666 date "2008-04-01" @default.
• W2146775666 modified "2023-10-13" @default.
• W2146775666 title "Lovastatin inhibits bronchial hyperresponsiveness by reducing RhoA signaling in rat allergic asthma" @default.
• W2146775666 cites W1509483174 @default.
• W2146775666 cites W1521884845 @default.
• W2146775666 cites W1597787921 @default.
• W2146775666 cites W1760927304 @default.
• W2146775666 cites W1960194948 @default.
• W2146775666 cites W1967583602 @default.
• W2146775666 cites W1967677280 @default.
• W2146775666 cites W1985223201 @default.
• W2146775666 cites W1991032022 @default.
• W2146775666 cites W1992316271 @default.
• W2146775666 cites W1994610108 @default.
• W2146775666 cites W1997411618 @default.
• W2146775666 cites W1999943358 @default.
• W2146775666 cites W2011845436 @default.
• W2146775666 cites W2011971534 @default.
• W2146775666 cites W2019390136 @default.
• W2146775666 cites W2021859728 @default.
• W2146775666 cites W2023542270 @default.
• W2146775666 cites W2030042069 @default.
• W2146775666 cites W2031180999 @default.
• W2146775666 cites W2039759783 @default.
• W2146775666 cites W2044686773 @default.
• W2146775666 cites W2052365898 @default.
• W2146775666 cites W2053072741 @default.
• W2146775666 cites W2059465572 @default.
• W2146775666 cites W2077792958 @default.
• W2146775666 cites W2078929931 @default.
• W2146775666 cites W2078975166 @default.
• W2146775666 cites W2084671094 @default.
• W2146775666 cites W2086370623 @default.
• W2146775666 cites W2096791952 @default.
• W2146775666 cites W2103599163 @default.
• W2146775666 cites W2107555017 @default.
• W2146775666 cites W2107920372 @default.
• W2146775666 cites W2109289603 @default.
• W2146775666 cites W2111778006 @default.
• W2146775666 cites W2114630275 @default.
• W2146775666 cites W2115427263 @default.
• W2146775666 cites W2119939122 @default.
• W2146775666 cites W2125900926 @default.
• W2146775666 cites W2127670733 @default.
• W2146775666 cites W2135514741 @default.
• W2146775666 cites W2138742704 @default.
• W2146775666 cites W2145448066 @default.
• W2146775666 cites W2149194612 @default.
• W2146775666 cites W2152347074 @default.
• W2146775666 cites W2152959383 @default.
• W2146775666 cites W2155598961 @default.
• W2146775666 cites W2157943033 @default.
• W2146775666 cites W2161583498 @default.
• W2146775666 cites W2162204439 @default.
• W2146775666 cites W2165464440 @default.
• W2146775666 cites W2247361254 @default.
• W2146775666 cites W2313177109 @default.
• W2146775666 cites W2415452458 @default.
• W2146775666 cites W1982211488 @default.
• W2146775666 cites W2087473532 @default.
• W2146775666 doi "https://doi.org/10.1152/ajplung.00531.2007" @default.
• W2146775666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18296496" @default.
• W2146775666 hasPublicationYear "2008" @default.
• W2146775666 type Work @default.
• W2146775666 sameAs 2146775666 @default.
• W2146775666 citedByCount "44" @default.
• W2146775666 countsByYear W21467756662012 @default.
• W2146775666 countsByYear W21467756662013 @default.
• W2146775666 countsByYear W21467756662014 @default.
• W2146775666 countsByYear W21467756662015 @default.
• W2146775666 countsByYear W21467756662016 @default.
• W2146775666 countsByYear W21467756662017 @default.
• W2146775666 countsByYear W21467756662018 @default.
• W2146775666 countsByYear W21467756662019 @default.
• W2146775666 countsByYear W21467756662020 @default.
• W2146775666 countsByYear W21467756662022 @default.
• W2146775666 countsByYear W21467756662023 @default.
• W2146775666 crossrefType "journal-article" @default.
• W2146775666 hasAuthorship W2146775666A5002276017 @default.
• W2146775666 hasAuthorship W2146775666A5004477338 @default.
• W2146775666 hasAuthorship W2146775666A5021925277 @default.
• W2146775666 hasAuthorship W2146775666A5058666311 @default.
• W2146775666 hasConcept C126322002 @default.
• W2146775666 hasConcept C134018914 @default.
• W2146775666 hasConcept C147483822 @default.
• W2146775666 hasConcept C165901193 @default.
• W2146775666 hasConcept C185592680 @default.
• W2146775666 hasConcept C203014093 @default.
• W2146775666 hasConcept C2776042228 @default.
• W2146775666 hasConcept C2776178081 @default.
• W2146775666 hasConcept C2776238763 @default.
• W2146775666 hasConcept C2776946954 @default.

• next