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- W2146784178 endingPage "305" @default.
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- W2146784178 abstract "A fascinating question of modern biology is how a limited number of signaling pathways generate biological diversity and crosstalk phenomena in vivo. Well-defined posttranslational modification patterns dictate the functions and interactions of proteins. The signal transducers and activators of transcription (STATs) are physiologically important cytokine-induced transcription factors. They are targeted by a multitude of posttranslational modifications that control and modulate signaling responses and gene expression. Beyond phosphorylation of serine and tyrosine residues, lysine acetylation has recently emerged as a critical modification regulating STAT functions. Interestingly, acetylation can determine STAT signaling codes by various molecular mechanisms, including the modulation of other posttranslational modifications. Here, we provide an overview on the acetylation of STATs and how this protein modification shapes cellular cytokine responses. We summarize recent advances in understanding the impact of STAT acetylation on cell growth, apoptosis, innate immunity, inflammation, and tumorigenesis. Furthermore, we discuss how STAT acetylation can be targeted by small molecules and we consider the possibility that additional molecules controlling STAT signaling are regulated by acetylation. Our review also summarizes evolutionary aspects and we show similarities between the acetylation-dependent control of STATs and other important molecules. We propose the concept that, similar to the ‘histone code’, distinct posttranslational modifications and their crosstalk orchestrate the functions and interactions of STAT proteins." @default.
- W2146784178 created "2016-06-24" @default.
- W2146784178 creator A5001180341 @default.
- W2146784178 creator A5015940174 @default.
- W2146784178 creator A5016364849 @default.
- W2146784178 creator A5051618960 @default.
- W2146784178 creator A5066778875 @default.
- W2146784178 date "2012-12-01" @default.
- W2146784178 modified "2023-09-26" @default.
- W2146784178 title "Acetylation modulates the STAT signaling code" @default.
- W2146784178 cites W1765001480 @default.
- W2146784178 cites W1931084569 @default.
- W2146784178 cites W1963851622 @default.
- W2146784178 cites W1963974600 @default.
- W2146784178 cites W1965828942 @default.
- W2146784178 cites W1968671346 @default.
- W2146784178 cites W1968754277 @default.
- W2146784178 cites W1969161297 @default.
- W2146784178 cites W1969931901 @default.
- W2146784178 cites W1976059452 @default.
- W2146784178 cites W1979228240 @default.
- W2146784178 cites W1983866601 @default.
- W2146784178 cites W1984573053 @default.
- W2146784178 cites W1984988736 @default.
- W2146784178 cites W1985843105 @default.
- W2146784178 cites W1986250542 @default.
- W2146784178 cites W1989156362 @default.
- W2146784178 cites W1990316655 @default.
- W2146784178 cites W1990884245 @default.
- W2146784178 cites W1991845993 @default.
- W2146784178 cites W1994941668 @default.
- W2146784178 cites W1997997873 @default.
- W2146784178 cites W2001678839 @default.
- W2146784178 cites W2002757138 @default.
- W2146784178 cites W2002902588 @default.
- W2146784178 cites W2003940278 @default.
- W2146784178 cites W2004935845 @default.
- W2146784178 cites W2005152816 @default.
- W2146784178 cites W2007479878 @default.
- W2146784178 cites W2009826707 @default.
- W2146784178 cites W2013108773 @default.
- W2146784178 cites W2017059819 @default.
- W2146784178 cites W2018050275 @default.
- W2146784178 cites W2018902760 @default.
- W2146784178 cites W2020238484 @default.
- W2146784178 cites W2021273655 @default.
- W2146784178 cites W2022682404 @default.
- W2146784178 cites W2029584718 @default.
- W2146784178 cites W2032672495 @default.
- W2146784178 cites W2034614265 @default.
- W2146784178 cites W2037299986 @default.
- W2146784178 cites W2037848797 @default.
- W2146784178 cites W2039883000 @default.
- W2146784178 cites W2041869213 @default.
- W2146784178 cites W2043927273 @default.
- W2146784178 cites W2045651220 @default.
- W2146784178 cites W2046628354 @default.
- W2146784178 cites W2047081723 @default.
- W2146784178 cites W2051181798 @default.
- W2146784178 cites W2053344100 @default.
- W2146784178 cites W2057351751 @default.
- W2146784178 cites W2057524890 @default.
- W2146784178 cites W2062505071 @default.
- W2146784178 cites W2065794552 @default.
- W2146784178 cites W2066079888 @default.
- W2146784178 cites W2066214252 @default.
- W2146784178 cites W2067432529 @default.
- W2146784178 cites W2067476313 @default.
- W2146784178 cites W2067791475 @default.
- W2146784178 cites W2068294387 @default.
- W2146784178 cites W2068681515 @default.
- W2146784178 cites W2068964035 @default.
- W2146784178 cites W2069699197 @default.
- W2146784178 cites W2071555702 @default.
- W2146784178 cites W2072669480 @default.
- W2146784178 cites W2073189570 @default.
- W2146784178 cites W2073851843 @default.
- W2146784178 cites W2073978750 @default.
- W2146784178 cites W2075068011 @default.
- W2146784178 cites W2075394846 @default.
- W2146784178 cites W2075490622 @default.
- W2146784178 cites W2078799236 @default.
- W2146784178 cites W2079870321 @default.
- W2146784178 cites W2081107312 @default.
- W2146784178 cites W2083019799 @default.
- W2146784178 cites W2088473907 @default.
- W2146784178 cites W2088665606 @default.
- W2146784178 cites W2088788982 @default.
- W2146784178 cites W2090094306 @default.
- W2146784178 cites W2090381051 @default.
- W2146784178 cites W2091069088 @default.
- W2146784178 cites W2091611701 @default.
- W2146784178 cites W2091906420 @default.
- W2146784178 cites W2093155739 @default.
- W2146784178 cites W2093312933 @default.
- W2146784178 cites W2099805317 @default.
- W2146784178 cites W2105345681 @default.
- W2146784178 cites W2107470925 @default.