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- W2146799303 abstract "An efficient process for preparing 3-methoxymethylquinolines, commencing from substituted anilines and 3-chloropropionyl chloride, has been developed. Reaction of substituted anilines with 3-chloropropionyl chloride in the presence of sodium carbonate produced 3-chloro-N- (substituted phenyl)propionamide, which was treated with dimethylformamide and phosphorus oxychloride (Vilsmeier Reaction) at 85 o C to give 2-chloro-3-chloromethyl substituted quinoline. Selective methoxylation of this dichloro intermediate with sodium methoxide in methanol at 45 o C gave 2-chloro-3-methoxymethyl substituted quinoline, which was dehalogenated by palladium catalyzed hydrodehalogenation to give 3-methoxymethyl substituted quinoline in nearly quantitative yield." @default.
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- W2146799303 date "2002-10-18" @default.
- W2146799303 modified "2023-10-01" @default.
- W2146799303 title "Efficient route to 3-methoxymethylquinolines – A precursor of 5-methoxymethylquinolinic acid" @default.
- W2146799303 doi "https://doi.org/10.3998/ark.5550190.0003.622" @default.
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