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• W2146800340 abstract "<h3>Objective</h3> To assess evolution in the care and health of very preterm babies between 1998 and 2003 after implementation of a regionalisation policy in France. <h3>Design</h3> Comparison of two population-based cohorts. <h3>Setting</h3> The Parisian region. <h3>Patients</h3> All live births at 24–31 weeks of gestation in 1997 (EPIPAGE study, n=488) and in 2003 (MOSAIC study, n=580). <h3>Interventions</h3> Implementation of regionalised perinatal networks. <h3>Main outcome measures</h3> In-hospital mortality and morbidity, including intraventricular haemorrhage (IVH) grade III and IV, cystic periventricular leucomalacia (PVL) and bronchopulmonary dysplasia (BPD). <h3>Results</h3> Over this period, babies born in level III units rose from 67% to 77% and use of antenatal corticosteroids, indicated deliveries and surfactant increased. In-hospital mortality and IVH grades III/IV declined, ORs of 0.66 (95% CI 0.46 to 0.95) and 0.27 (95% CI 0.15 to 0.47), respectively, while PVL and BPD stayed constant. The rate of very preterm babies discharged alive per 1000 total births increased by 18%, but declined for babies with severe brain lesions. <h3>Conclusions</h3> The authors found improvements in mortality and morbidity for very preterm babies and changes in their care over a 6-year period following reinforcement of regionalisation policies." @default.
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• W2146800340 date "2009-04-23" @default.
• W2146800340 modified "2023-10-18" @default.
• W2146800340 title "Changes in care and outcome of very preterm babies in the Parisian region between 1998 and 2003" @default.
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• W2146800340 doi "https://doi.org/10.1136/adc.2008.156745" @default.
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