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• W2146808192 abstract "The neurotransmitter dopamine (DA) is known to inhibit prolactin (PRL) secretion and the proliferation of lactotropes in the pituitary gland. Dopamine-2 (D2) receptor short (D2S) isoform is expressed in a reduced level while the D2 receptor long (D2L) isoform is expressed in an elevated level during estradiol (E 2 )-induced PRL production and cell proliferation in lactotropes. To evaluate the role of these D2 receptor isoforms in E 2 -regulated lactotropic cell function, we compared E 2 effects on the level of PRL, cell proliferation, and G proteins in enriched lactotropes and lactotrope-derived PR1 cells containing only D2S isoform (D2S cells), D2L isoform (D2L cells), or no D2 receptor (V cells). Additionally, we determined the effects of G protein blockade on the E 2 -induced PRL production and cell proliferation in these cells. We here show that E 2 actions on G proteins, PRL production, and cell proliferation were maximally achieved in D2S cells, oppositely or marginally achieved in D2L cells, and absent in V cells. We also show that the DA and pertussis toxin modulations of E 2 actions on PRL, G proteins, and cell proliferation were maximally achieved in D2S cells compared with in D2L or V cells. Furthermore, we provide evidence for the existence of an inhibitory action of Gi3 on Gs that is under the control of the D2S receptor and is inhibited by E 2 . These results suggest that the suppression of D2S-regulated Gi3 inhibition of Gs protein may be one of the mechanisms controlling E 2 -activated PRL synthesis and cell proliferation in lactotropes." @default.
• W2146808192 created "2016-06-24" @default.
• W2146808192 creator A5025737356 @default.
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• W2146808192 date "2012-05-09" @default.
• W2146808192 modified "2023-09-27" @default.
• W2146808192 title "Estrogen inhibits D2S receptor-regulated Gi3 and Gs protein interactions to stimulate prolactin production and cell proliferation in lactotropic cells" @default.
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• W2146808192 doi "https://doi.org/10.1530/joe-12-0125" @default.
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