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• W2146828069 abstract "Rinta S, Airas L, Elovaara I. Is the modulatory effect of pregnancy in multiple sclerosis associated with changes in blood apoptotic molecules? Acta Neurol Scand: 2010: 122: 168–174. © 2010 John Wiley & Sons A/S. Objective – We examined whether the modulatory effect of pregnancy on multiple sclerosis (MS) is associated with changes in the apoptotic molecules in sera. Subjects and methods – The serum levels of tumor necrosis factor-related apoptosis-inducing ligand (sTRAIL), sFas, Fas ligand (sFasL) and macrophage migration inhibitory factor were analyzed from 19 MS patients and 14 controls during late pregnancy and post-partum. The obtained results were related to disease activity and the progression of MS. Results – Disease activity decreased during pregnancy. The levels of sTRAIL and sFasL increased from late pregnancy to post-partum situation in both MS patients and controls, but in MS patients the changes in the levels of sTRAIL from late pregnancy to post-partum were smaller than in controls. Conclusions – Post-partum upregulation of TRAIL and FasL seems to be caused by physiologic reactivation of the mother’s immune system after pregnancy. An increased risk of relapses in MS post-partum may be associated with changes in the immunomodulatory potential of these apoptotic molecules." @default.
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• W2146828069 date "2010-08-03" @default.
• W2146828069 modified "2023-09-24" @default.
• W2146828069 title "Is the modulatory effect of pregnancy in multiple sclerosis associated with changes in blood apoptotic molecules?" @default.
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• W2146828069 doi "https://doi.org/10.1111/j.1600-0404.2009.01301.x" @default.
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