Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146838480> ?p ?o ?g. }
- W2146838480 endingPage "466" @default.
- W2146838480 startingPage "458" @default.
- W2146838480 abstract "Though implicated in vascular remodelling, a role for the resistin-like molecule (RELM)-β in human airway remodelling remains unexplored. We hypothesised that RELM-β expression is increased in the airways of asthmatics and regulates airways epithelial cell function. Expression of RELM-β in the bronchial mucosa and its concentrations in bronchoalveolar lavage (BAL) fluid from asthmatics and controls were measured by immunohistochemistry and ELISA, respectively. Proliferation assays, Western blotting, ELISA and real-time PCR were employed to detect effects of RELM-β on airways epithelial cells. RELM-β expression was increased in the bronchial mucosa and BAL fluid of asthmatics compared with controls. In the asthmatics, the numbers of mucosal RELM-β+ cells correlated inversely with forced expiratory volume in 1 s (r=-0.531, p=0.016), while the numbers of epithelial RELM-β+ cells correlated positively with those of mucin (MUC)5AC+ cells. <i>In vitro</i>, interleukin-13 enhanced RELM-β expression by primary human airways epithelial cells, while RELM-β itself acted on these cells to induce proliferation, expression of MUC5AC, extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK)-phosphatidylinositol 3-kinase (PI3K)/Akt phosphorylation and elevated expression of transforming growth factor-β2, epidermal growth factor and vascular endothelial growth factor. RELM-β has the potential to contribute to airway remodelling in diseases such as asthma by acting on epithelial cells to increase proliferation, mucin and growth factor production, at least partly <i>via</i> ERK/MAPK-PI3K/Akt signalling pathways." @default.
- W2146838480 created "2016-06-24" @default.
- W2146838480 creator A5004101302 @default.
- W2146838480 creator A5013294324 @default.
- W2146838480 creator A5023307885 @default.
- W2146838480 creator A5028740838 @default.
- W2146838480 creator A5030297121 @default.
- W2146838480 creator A5043703051 @default.
- W2146838480 creator A5043708055 @default.
- W2146838480 creator A5044019608 @default.
- W2146838480 creator A5063631598 @default.
- W2146838480 creator A5084087276 @default.
- W2146838480 creator A5089714007 @default.
- W2146838480 date "2011-08-04" @default.
- W2146838480 modified "2023-10-16" @default.
- W2146838480 title "Resistin-like molecule- is a human airway remodelling mediator" @default.
- W2146838480 cites W148985966 @default.
- W2146838480 cites W1540026419 @default.
- W2146838480 cites W1972435690 @default.
- W2146838480 cites W1973660213 @default.
- W2146838480 cites W1981720530 @default.
- W2146838480 cites W1983052547 @default.
- W2146838480 cites W2000228858 @default.
- W2146838480 cites W2007026199 @default.
- W2146838480 cites W2036797577 @default.
- W2146838480 cites W2037261076 @default.
- W2146838480 cites W2053735968 @default.
- W2146838480 cites W2061262914 @default.
- W2146838480 cites W2065891103 @default.
- W2146838480 cites W2076381752 @default.
- W2146838480 cites W2077321668 @default.
- W2146838480 cites W2096998001 @default.
- W2146838480 cites W2107496415 @default.
- W2146838480 cites W2110244190 @default.
- W2146838480 cites W2121730825 @default.
- W2146838480 cites W2125245491 @default.
- W2146838480 cites W2127203245 @default.
- W2146838480 cites W2128337755 @default.
- W2146838480 cites W2139889887 @default.
- W2146838480 cites W2145147024 @default.
- W2146838480 cites W2147684493 @default.
- W2146838480 cites W2151041131 @default.
- W2146838480 cites W2162593372 @default.
- W2146838480 cites W2163029508 @default.
- W2146838480 cites W2165694323 @default.
- W2146838480 cites W2170948066 @default.
- W2146838480 doi "https://doi.org/10.1183/09031936.00107811" @default.
- W2146838480 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21828035" @default.
- W2146838480 hasPublicationYear "2011" @default.
- W2146838480 type Work @default.
- W2146838480 sameAs 2146838480 @default.
- W2146838480 citedByCount "35" @default.
- W2146838480 countsByYear W21468384802012 @default.
- W2146838480 countsByYear W21468384802013 @default.
- W2146838480 countsByYear W21468384802014 @default.
- W2146838480 countsByYear W21468384802015 @default.
- W2146838480 countsByYear W21468384802016 @default.
- W2146838480 countsByYear W21468384802017 @default.
- W2146838480 countsByYear W21468384802018 @default.
- W2146838480 countsByYear W21468384802020 @default.
- W2146838480 countsByYear W21468384802021 @default.
- W2146838480 countsByYear W21468384802022 @default.
- W2146838480 countsByYear W21468384802023 @default.
- W2146838480 crossrefType "journal-article" @default.
- W2146838480 hasAuthorship W2146838480A5004101302 @default.
- W2146838480 hasAuthorship W2146838480A5013294324 @default.
- W2146838480 hasAuthorship W2146838480A5023307885 @default.
- W2146838480 hasAuthorship W2146838480A5028740838 @default.
- W2146838480 hasAuthorship W2146838480A5030297121 @default.
- W2146838480 hasAuthorship W2146838480A5043703051 @default.
- W2146838480 hasAuthorship W2146838480A5043708055 @default.
- W2146838480 hasAuthorship W2146838480A5044019608 @default.
- W2146838480 hasAuthorship W2146838480A5063631598 @default.
- W2146838480 hasAuthorship W2146838480A5084087276 @default.
- W2146838480 hasAuthorship W2146838480A5089714007 @default.
- W2146838480 hasBestOaLocation W21468384801 @default.
- W2146838480 hasConcept C126322002 @default.
- W2146838480 hasConcept C142724271 @default.
- W2146838480 hasConcept C170493617 @default.
- W2146838480 hasConcept C179264091 @default.
- W2146838480 hasConcept C184235292 @default.
- W2146838480 hasConcept C203014093 @default.
- W2146838480 hasConcept C2775960820 @default.
- W2146838480 hasConcept C2776362946 @default.
- W2146838480 hasConcept C2777714996 @default.
- W2146838480 hasConcept C2777961210 @default.
- W2146838480 hasConcept C502942594 @default.
- W2146838480 hasConcept C529295009 @default.
- W2146838480 hasConcept C54355233 @default.
- W2146838480 hasConcept C57074206 @default.
- W2146838480 hasConcept C62478195 @default.
- W2146838480 hasConcept C71924100 @default.
- W2146838480 hasConcept C75217442 @default.
- W2146838480 hasConcept C81885089 @default.
- W2146838480 hasConcept C86554907 @default.
- W2146838480 hasConcept C86803240 @default.
- W2146838480 hasConcept C87568996 @default.
- W2146838480 hasConcept C95444343 @default.