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• W2146872012 abstract "PURPOSE. To characterize baseline transport properties: hydraulic conductivity (Lp), albumin permeability (Pe), and transendothelial electrical resistance (TER) of bovine retinal microvascular endothelial cells (RMEC) in the development of an in vitro model of the blood-retinal barrier (BRB). METHODS. RMEC were grown on porous, polycarbonate filters for determination of the number of days required to achieve minimal transport rates. Lp, Pe, and TER were measured by utilizing a bubble tracking spectrophotometer, by quantifying the diffusional movement of fluorescein isothiocyanate-labeled albumin, and by utilizing a Millipore electrical resistance meter, respectively. RESULTS. Lp decreased significantly from 7.82 ± 0.85 × 10 -7 (mean ± SEM) cm/sec/cm H 2 O at post-plating Day 5 to 1.44 ± 0.26 × 10 -7 cm/sec/cm H 2 O at Day 9. Pe of the monolayer also decreased progressively with days post-plating from 3.44 ± 0.53 × 10 -6 cm/sec at Day 7 to a minimum of 1.95 ± 0.29 × 10 -6 cm/sec at Day 11. Peak TER fluctuated until Day 7, when it began to steadily increase from 17.14 ohm·cm 2 to a peak value of 25.42 ohm·cm 2 at Day 10, decreasing from then on to 22.24 ohm·cm 2 on Day 12. Known disrupters of the BRB, NECA and VEGF, elicited significant increase in RMEC Lp showing the sensitivity of this model to pharmacological alterations. CONCLUSIONS. Our data indicate that RMEC grown on polycarbonate filters form a restrictive monolayer of cells, which exhibit dynamic alterations in response to pharmacological agents, thus demonstrating an in vitro model of the BRB. Future studies with the model may offer insights into the pathogenesis of retinal vascular diseases and allow convenient testing of pharmacological interventions." @default.
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• W2146872012 date "1997-01-01" @default.
• W2146872012 modified "2023-10-14" @default.
• W2146872012 title "Physiological transport properties of cultured retinal microvascular endothelial cell monolayers" @default.
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• W2146872012 doi "https://doi.org/10.1076/ceyr.16.8.761.8991" @default.
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