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- W2146873166 abstract "Patients with both a prolonged activated partial thromboplastin time (APTT) and suspected of having lupus anticoagulants (LA) frequently meet the laboratory criteria for LA, so detection is not difficult. In contrast, it is more difficult to diagnose LA in patients with no personal or family history of bleeding or thrombosis, only moderately prolonged APTT, or those cases in which the reason for the coagulation study is pre-operative screening. Recently, a retrospective study in children has shown that in the majority of these cases the presence of LA is not associated with clinical complications and is transitory [ [1] Male C. Lechner K. Eichinger S. Kyrle P.A. Kapiotis S. Wank H. et al. Clinical significance and course of lupus anticoagulants in children. J Pediatr. 1999; 134: 199-205 Abstract Full Text Full Text PDF PubMed Scopus (119) Google Scholar ]. Our experience coincides with that of the authors, and we are in agreement on the variability of the levels of LA and their effects on diagnostic tests [ [2] Male C. Lechner K. Speiser W. Pabinger I. Transient lupus anticoagulants in children: stepwise disappearance of diagnostic features. Thromb Haemost. 2000; 83: 174-175 PubMed Google Scholar ]. Lower titer antibodies prolong the APTT to a lesser extent, mixing studies are often equivocal, and the confirmation tests are usually negative; therefore it is difficult to establish a reliable diagnosis." @default.
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- W2146873166 date "2005-01-01" @default.
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- W2146873166 title "Detection of low levels of lupus anticoagulant antibodies" @default.
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- W2146873166 doi "https://doi.org/10.1016/j.thromres.2005.04.027" @default.
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