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• W2146875212 abstract "Pneumonia, along with influenza, is the leading cause of mortality associated with infectious diseases in the USA. Tigecycline is a novel antimicrobial agent that is active against a broad spectrum of pathogens. Our objective is to review the literature about the efficacy of tigecycline in community-acquired pneumonia (CAP). Data from various sources, including Pubmed, the European Medicines Agency (EMEA) and the US FDA were appraised. Tigecycline was found to be noninferior compared with levofloxacin for the treatment of patients with bacterial CAP requiring hospitalization. Recently, the drug was approved for the treatment of these patients by the FDA, but owing to some concerns, its application in the EMEA has been withdrawn. In addition, in a recent study concerns were expressed about the efficacy of tigecycline in the lungs using the current dosage. More data are needed about the pharmacokinetics of tigecycline in the lungs and its efficacy in severe CAP." @default.
• W2146875212 created "2016-06-24" @default.
• W2146875212 creator A5003149095 @default.
• W2146875212 creator A5047582800 @default.
• W2146875212 date "2009-10-01" @default.
• W2146875212 modified "2023-09-27" @default.
• W2146875212 title "Tigecycline for the treatment of patients with community-acquired pneumonia requiring hospitalization" @default.
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• W2146875212 doi "https://doi.org/10.1586/eri.09.73" @default.
• W2146875212 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19803699" @default.
• W2146875212 hasPublicationYear "2009" @default.
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