FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146879478> ?p ?o ?g. }

• W2146879478 endingPage "353" @default.
• W2146879478 startingPage "347" @default.
• W2146879478 abstract "3-D Structure of Serum Paraoxonase 1 Sheds Light on Its Activity, Stability, Solubility and Crystallizability Serum paraoxonases (PONs) exhibit a wide range of physiologically important hydrolytic activities, including drug metabolism and detoxification of nerve gases. PON1 and PON3 reside on high-density lipoprotein (HDL) (the good cholesterol), and are involved in the alleviation of atherosclerosis. Members of the PON family have been identified not only in mammals and other vertebrates, but also in invertebrates. We earlier described the first crystal structure of a PON family member, a directly-evolved variant of PON1, at 2.2 Å resolution. PON1 is a 6-bladed beta-propeller with a unique active-site lid which is also involved in binding to HDL. The 3-D structure, taken together with directed evolution studies, permitted analysis of mutations which enhanced the stability, solubility and crystallizability of this PON1 variant. The structure permits a detailed description of PON1's active site and suggests possible mechanisms for its catalytic activity on certain substrates." @default.
• W2146879478 created "2016-06-24" @default.
• W2146879478 creator A5000046630 @default.
• W2146879478 creator A5025933576 @default.
• W2146879478 creator A5028400719 @default.
• W2146879478 creator A5050870388 @default.
• W2146879478 creator A5053992759 @default.
• W2146879478 creator A5064617969 @default.
• W2146879478 creator A5068412606 @default.
• W2146879478 creator A5084283904 @default.
• W2146879478 creator A5086939196 @default.
• W2146879478 date "2007-09-01" @default.
• W2146879478 modified "2023-10-05" @default.
• W2146879478 title "3-D Structure of Serum Paraoxonase 1 Sheds Light on Its Activity, Stability, Solubility and Crystallizability" @default.
• W2146879478 cites W1671050155 @default.
• W2146879478 cites W1985118646 @default.
• W2146879478 cites W1990804733 @default.
• W2146879478 cites W2015289968 @default.
• W2146879478 cites W2017181323 @default.
• W2146879478 cites W2021395497 @default.
• W2146879478 cites W2026999474 @default.
• W2146879478 cites W2028312892 @default.
• W2146879478 cites W2046378700 @default.
• W2146879478 cites W2054847996 @default.
• W2146879478 cites W2061663562 @default.
• W2146879478 cites W2078910490 @default.
• W2146879478 cites W2085382883 @default.
• W2146879478 cites W2107378767 @default.
• W2146879478 cites W2114197469 @default.
• W2146879478 cites W2133566550 @default.
• W2146879478 cites W2160585315 @default.
• W2146879478 cites W2161414810 @default.
• W2146879478 cites W2161964918 @default.
• W2146879478 cites W4251722549 @default.
• W2146879478 cites W4256475235 @default.
• W2146879478 doi "https://doi.org/10.2478/v10004-007-0028-0" @default.
• W2146879478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17913690" @default.
• W2146879478 hasPublicationYear "2007" @default.
• W2146879478 type Work @default.
• W2146879478 sameAs 2146879478 @default.
• W2146879478 citedByCount "32" @default.
• W2146879478 countsByYear W21468794782012 @default.
• W2146879478 countsByYear W21468794782013 @default.
• W2146879478 countsByYear W21468794782014 @default.
• W2146879478 countsByYear W21468794782015 @default.
• W2146879478 countsByYear W21468794782016 @default.
• W2146879478 countsByYear W21468794782017 @default.
• W2146879478 countsByYear W21468794782018 @default.
• W2146879478 countsByYear W21468794782019 @default.
• W2146879478 countsByYear W21468794782021 @default.
• W2146879478 countsByYear W21468794782023 @default.
• W2146879478 crossrefType "journal-article" @default.
• W2146879478 hasAuthorship W2146879478A5000046630 @default.
• W2146879478 hasAuthorship W2146879478A5025933576 @default.
• W2146879478 hasAuthorship W2146879478A5028400719 @default.
• W2146879478 hasAuthorship W2146879478A5050870388 @default.
• W2146879478 hasAuthorship W2146879478A5053992759 @default.
• W2146879478 hasAuthorship W2146879478A5064617969 @default.
• W2146879478 hasAuthorship W2146879478A5068412606 @default.
• W2146879478 hasAuthorship W2146879478A5084283904 @default.
• W2146879478 hasAuthorship W2146879478A5086939196 @default.
• W2146879478 hasBestOaLocation W21468794781 @default.
• W2146879478 hasConcept C104317684 @default.
• W2146879478 hasConcept C12554922 @default.
• W2146879478 hasConcept C135763542 @default.
• W2146879478 hasConcept C155574463 @default.
• W2146879478 hasConcept C178790620 @default.
• W2146879478 hasConcept C181199279 @default.
• W2146879478 hasConcept C185592680 @default.
• W2146879478 hasConcept C2776509667 @default.
• W2146879478 hasConcept C2780120296 @default.
• W2146879478 hasConcept C37501387 @default.
• W2146879478 hasConcept C55493867 @default.
• W2146879478 hasConcept C86803240 @default.
• W2146879478 hasConceptScore W2146879478C104317684 @default.
• W2146879478 hasConceptScore W2146879478C12554922 @default.
• W2146879478 hasConceptScore W2146879478C135763542 @default.
• W2146879478 hasConceptScore W2146879478C155574463 @default.
• W2146879478 hasConceptScore W2146879478C178790620 @default.
• W2146879478 hasConceptScore W2146879478C181199279 @default.
• W2146879478 hasConceptScore W2146879478C185592680 @default.
• W2146879478 hasConceptScore W2146879478C2776509667 @default.
• W2146879478 hasConceptScore W2146879478C2780120296 @default.
• W2146879478 hasConceptScore W2146879478C37501387 @default.
• W2146879478 hasConceptScore W2146879478C55493867 @default.
• W2146879478 hasConceptScore W2146879478C86803240 @default.
• W2146879478 hasIssue "3" @default.
• W2146879478 hasLocation W21468794781 @default.
• W2146879478 hasLocation W21468794782 @default.
• W2146879478 hasLocation W21468794783 @default.
• W2146879478 hasLocation W21468794784 @default.
• W2146879478 hasOpenAccess W2146879478 @default.
• W2146879478 hasPrimaryLocation W21468794781 @default.
• W2146879478 hasRelatedWork W1969061170 @default.
• W2146879478 hasRelatedWork W1996554492 @default.
• W2146879478 hasRelatedWork W2044410014 @default.
• W2146879478 hasRelatedWork W2073184928 @default.
• W2146879478 hasRelatedWork W2111891584 @default.

• next