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- W2146885083 abstract "Sequestration of the mature Plasmodium falciparum forms complicates detection, quantification and molecular analysis of human infections. Whether the circulating parasites represent all or only a subset of co-infecting genotypes is unclear. We have investigated this issue and compared placenta and peripheral blood msp1 and msp2 genotypes in 58 women delivering with an ICT-positive placenta in Guediawaye, Senegal. Most placenta (91%) and blood samples (98%) were multiply infected. Multiplicity of infection was positively correlated in both tissues. However, the placental and circulating genotype profiles differed markedly. Only 10% of matched peripheral blood/placenta samples had identical genotypes, whereas 74% had only partially concordant genotypes, with some alleles detected in both tissues, together with additional allele(s) detected in one tissue only. Eight women (14%) had totally discordant placental and peripheral blood genotypes. Thus, in the vast majority of cases, some sequestered genotypes remain hidden, undetected in the peripheral circulation, indicating that analysis of peripheral parasites generates a partial picture of a P. falciparum infection." @default.
- W2146885083 created "2016-06-24" @default.
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- W2146885083 date "2002-12-01" @default.
- W2146885083 modified "2023-10-18" @default.
- W2146885083 title "Hidden Plasmodium falciparum parasites in human infections: different genotype distribution in the peripheral circulation and in the placenta" @default.
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- W2146885083 doi "https://doi.org/10.1016/s1567-1348(02)00085-0" @default.
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