Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146892250> ?p ?o ?g. }
- W2146892250 endingPage "42" @default.
- W2146892250 startingPage "6534" @default.
- W2146892250 abstract "Apoptosis is accompanied by major changes in ion compartmentalization and transmembrane potentials. Thymocyte apoptosis is characterized by an early dissipation of the mitochondrial transmembrane potential, with transient mitochondrial swelling and a subsequent loss of plasma membrane potential (DeltaP sip) related to the loss of cytosolic K+, cellular shrinkage, and DNA fragmentation. Thus, a gross perturbation of DeltaPsip occurs at the postmitochondrial stage of apoptosis. Unexpectedly, we found that blockade of plasma membrane K+ channels by tetrapentylammonium (TPA), which leads to a DeltaP sip collapse, can prevent the thymocyte apoptosis induced by exposure to the glucocorticoid receptor agonist dexamethasone, the topoisomerase inhibitor etoposide, gamma-irradiation, or ceramide. The TPA-mediated protective effect extends to all features of apoptosis, including dissipation of the mitochondrial transmembrane potential, loss of cytosolic K+, phosphatidylserine exposure on the cell surface, chromatin condensation, as well as caspase and endonuclease activation. In strict contrast, TPA is an ineffective inhibitor when cell death is induced by the potassium ionophore valinomycin, the specific mitochondrial benzodiazepine ligand PK11195, or by primary caspase activation by Fas/CD95 cross-linking. These results underline the importance of K+ channels for the regulation of some but not all pathways leading to thymocyte apoptosis." @default.
- W2146892250 created "2016-06-24" @default.
- W2146892250 creator A5018256637 @default.
- W2146892250 creator A5031121773 @default.
- W2146892250 creator A5047109577 @default.
- W2146892250 creator A5063225041 @default.
- W2146892250 creator A5068539997 @default.
- W2146892250 creator A5071329699 @default.
- W2146892250 creator A5075296559 @default.
- W2146892250 creator A5084267186 @default.
- W2146892250 creator A5089947551 @default.
- W2146892250 date "1999-06-01" @default.
- W2146892250 modified "2023-10-13" @default.
- W2146892250 title "Plasma membrane potential in thymocyte apoptosis." @default.
- W2146892250 cites W125106425 @default.
- W2146892250 cites W1495243184 @default.
- W2146892250 cites W1503225378 @default.
- W2146892250 cites W1510054089 @default.
- W2146892250 cites W1522329101 @default.
- W2146892250 cites W1553062142 @default.
- W2146892250 cites W1567258255 @default.
- W2146892250 cites W158669183 @default.
- W2146892250 cites W1745634660 @default.
- W2146892250 cites W1784106556 @default.
- W2146892250 cites W1860582510 @default.
- W2146892250 cites W1873458020 @default.
- W2146892250 cites W1968599399 @default.
- W2146892250 cites W1976226379 @default.
- W2146892250 cites W1979129905 @default.
- W2146892250 cites W1979369766 @default.
- W2146892250 cites W1983294136 @default.
- W2146892250 cites W1983721816 @default.
- W2146892250 cites W1987563269 @default.
- W2146892250 cites W1996401496 @default.
- W2146892250 cites W2000167364 @default.
- W2146892250 cites W2005430818 @default.
- W2146892250 cites W2008374272 @default.
- W2146892250 cites W2008479667 @default.
- W2146892250 cites W2009222624 @default.
- W2146892250 cites W2011495375 @default.
- W2146892250 cites W2020321505 @default.
- W2146892250 cites W2024651898 @default.
- W2146892250 cites W2029247738 @default.
- W2146892250 cites W2038370680 @default.
- W2146892250 cites W2041466047 @default.
- W2146892250 cites W2048692719 @default.
- W2146892250 cites W2049873418 @default.
- W2146892250 cites W2052540803 @default.
- W2146892250 cites W2055094310 @default.
- W2146892250 cites W2057203237 @default.
- W2146892250 cites W2057308709 @default.
- W2146892250 cites W2063385957 @default.
- W2146892250 cites W2065635863 @default.
- W2146892250 cites W2070864725 @default.
- W2146892250 cites W2076610743 @default.
- W2146892250 cites W2077987011 @default.
- W2146892250 cites W2078223586 @default.
- W2146892250 cites W2078532650 @default.
- W2146892250 cites W2081145901 @default.
- W2146892250 cites W2082490296 @default.
- W2146892250 cites W2084248263 @default.
- W2146892250 cites W2085664253 @default.
- W2146892250 cites W2094334993 @default.
- W2146892250 cites W2095370647 @default.
- W2146892250 cites W2096012158 @default.
- W2146892250 cites W2098712005 @default.
- W2146892250 cites W2101575450 @default.
- W2146892250 cites W2108131089 @default.
- W2146892250 cites W2113999599 @default.
- W2146892250 cites W2114388515 @default.
- W2146892250 cites W2120473562 @default.
- W2146892250 cites W2125469822 @default.
- W2146892250 cites W2141578443 @default.
- W2146892250 cites W2141810544 @default.
- W2146892250 cites W2147357406 @default.
- W2146892250 cites W2149321851 @default.
- W2146892250 cites W2149429457 @default.
- W2146892250 cites W2149967205 @default.
- W2146892250 cites W2150476216 @default.
- W2146892250 cites W2151404647 @default.
- W2146892250 cites W2154346380 @default.
- W2146892250 cites W2160875934 @default.
- W2146892250 cites W2164819106 @default.
- W2146892250 cites W2167293805 @default.
- W2146892250 cites W2169486888 @default.
- W2146892250 cites W2170488287 @default.
- W2146892250 cites W2170961323 @default.
- W2146892250 cites W2172205541 @default.
- W2146892250 cites W2476344749 @default.
- W2146892250 cites W25044289 @default.
- W2146892250 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10352269" @default.
- W2146892250 hasPublicationYear "1999" @default.
- W2146892250 type Work @default.
- W2146892250 sameAs 2146892250 @default.
- W2146892250 citedByCount "36" @default.
- W2146892250 countsByYear W21468922502012 @default.
- W2146892250 countsByYear W21468922502013 @default.
- W2146892250 countsByYear W21468922502016 @default.