FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146916411> ?p ?o ?g. }

• W2146916411 abstract "Hepatocyte growth factor (HGF), an antimitogenic factor for HepG2 cells, increased mRNA and protein levels of UGT1A1 and CYP2B6, as well as the endogenous cyclin-dependent kinase (CDK) inhibitors p16, p21, and p27 in HepG2 cells but not in HuH6, Caco2, or MCF7 cells. Treatment with 1,4-diamino-2,3-dicyano-1,4-bis(methylthio)butadiene (U0126) (an extracellular signal-regulated kinase inhibitor) suppressed the HGF-induced expression of UGT1A1 and CYP2B6, as well as p16, p21, and p27 in HepG2 cells. The CDK inhibitor roscovitine also enhanced the expression of UGT1A1, CYP2B6, and CYP3A4. Transfection of anti-CDK2 siRNA led to elevated levels of UGT1A1, CYP2B6, and CYP3A4 in HepG2 and SW480 cells, whereas anti-CDK4 small interfering RNA (siRNA) did not significantly enhance the expression of these enzymes. In fact, CDK2 activity was decreased in HGF-treated HepG2 cells. In cells arrested in S phase by a thymidine block and then released into a synchronous cell cycle, there was a clear dissociation among the activation of CDK2 and the expression of UGT1A1, CYP2B6, and CYP3A4. Furthermore, the induction of CYP3A4 but not UGT1A1 or CYP2B6 mRNA expression by roscovitine was repressed in pregnane X receptor (PXR) siRNA-transfected HepG2 cells. Transfection with constitutive androstane receptor siRNA or PXR siRNA in HepG2 cells did not repress the HGF-stimulated expression of UGT1A1 mRNA. Taken together, our results show that the expression of UGT1A1 and CYP2B6 is negatively regulated through a CDK2 signaling pathway linked to cell cycle progression in HepG2 and SW480 cells, the mechanism of which may differ from that of CYP3A4 expression through PXR phosphorylated by CDK2." @default.
• W2146916411 created "2016-06-24" @default.
• W2146916411 creator A5007615482 @default.
• W2146916411 creator A5034195657 @default.
• W2146916411 creator A5035885340 @default.
• W2146916411 creator A5048224957 @default.
• W2146916411 creator A5062297194 @default.
• W2146916411 creator A5081392938 @default.
• W2146916411 date "2009-10-01" @default.
• W2146916411 modified "2023-09-24" @default.
• W2146916411 title "Induction of UGT1A1 and CYP2B6 by an Antimitogenic Factor in HepG2 Cells Is Mediated through Suppression of Cyclin-Dependent Kinase 2 Activity: Cell Cycle-Dependent Expression" @default.
• W2146916411 cites W1583571078 @default.
• W2146916411 cites W1970194297 @default.
• W2146916411 cites W1971060960 @default.
• W2146916411 cites W1971549167 @default.
• W2146916411 cites W1977374138 @default.
• W2146916411 cites W1989930134 @default.
• W2146916411 cites W1995727180 @default.
• W2146916411 cites W2013594177 @default.
• W2146916411 cites W2015021809 @default.
• W2146916411 cites W2021941361 @default.
• W2146916411 cites W2025215722 @default.
• W2146916411 cites W2027590613 @default.
• W2146916411 cites W2029467685 @default.
• W2146916411 cites W2031223075 @default.
• W2146916411 cites W2045794991 @default.
• W2146916411 cites W2051782283 @default.
• W2146916411 cites W2053755961 @default.
• W2146916411 cites W2055355210 @default.
• W2146916411 cites W2056331663 @default.
• W2146916411 cites W2059349834 @default.
• W2146916411 cites W2061132293 @default.
• W2146916411 cites W2063203910 @default.
• W2146916411 cites W2084720330 @default.
• W2146916411 cites W2086268693 @default.
• W2146916411 cites W2108131577 @default.
• W2146916411 cites W2111842648 @default.
• W2146916411 cites W2115494889 @default.
• W2146916411 cites W2120433679 @default.
• W2146916411 cites W2121688650 @default.
• W2146916411 cites W2132804094 @default.
• W2146916411 cites W2135129680 @default.
• W2146916411 cites W2136560821 @default.
• W2146916411 cites W2142406561 @default.
• W2146916411 cites W2142586776 @default.
• W2146916411 cites W2145327188 @default.
• W2146916411 cites W2160583076 @default.
• W2146916411 cites W2163210901 @default.
• W2146916411 cites W2166279203 @default.
• W2146916411 cites W2171411510 @default.
• W2146916411 doi "https://doi.org/10.1124/dmd.109.029785" @default.
• W2146916411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19797611" @default.
• W2146916411 hasPublicationYear "2009" @default.
• W2146916411 type Work @default.
• W2146916411 sameAs 2146916411 @default.
• W2146916411 citedByCount "22" @default.
• W2146916411 countsByYear W21469164112012 @default.
• W2146916411 countsByYear W21469164112013 @default.
• W2146916411 countsByYear W21469164112014 @default.
• W2146916411 countsByYear W21469164112015 @default.
• W2146916411 countsByYear W21469164112016 @default.
• W2146916411 countsByYear W21469164112017 @default.
• W2146916411 countsByYear W21469164112020 @default.
• W2146916411 crossrefType "journal-article" @default.
• W2146916411 hasAuthorship W2146916411A5007615482 @default.
• W2146916411 hasAuthorship W2146916411A5034195657 @default.
• W2146916411 hasAuthorship W2146916411A5035885340 @default.
• W2146916411 hasAuthorship W2146916411A5048224957 @default.
• W2146916411 hasAuthorship W2146916411A5062297194 @default.
• W2146916411 hasAuthorship W2146916411A5081392938 @default.
• W2146916411 hasConcept C104317684 @default.
• W2146916411 hasConcept C109650736 @default.
• W2146916411 hasConcept C124320809 @default.
• W2146916411 hasConcept C132040763 @default.
• W2146916411 hasConcept C1491633281 @default.
• W2146916411 hasConcept C153911025 @default.
• W2146916411 hasConcept C170493617 @default.
• W2146916411 hasConcept C181199279 @default.
• W2146916411 hasConcept C184235292 @default.
• W2146916411 hasConcept C185592680 @default.
• W2146916411 hasConcept C193264327 @default.
• W2146916411 hasConcept C22615655 @default.
• W2146916411 hasConcept C2776996007 @default.
• W2146916411 hasConcept C2778298596 @default.
• W2146916411 hasConcept C29537977 @default.
• W2146916411 hasConcept C50605568 @default.
• W2146916411 hasConcept C526171541 @default.
• W2146916411 hasConcept C54009773 @default.
• W2146916411 hasConcept C54355233 @default.
• W2146916411 hasConcept C55493867 @default.
• W2146916411 hasConcept C63932345 @default.
• W2146916411 hasConcept C81885089 @default.
• W2146916411 hasConcept C82495950 @default.
• W2146916411 hasConcept C86339819 @default.
• W2146916411 hasConcept C86803240 @default.
• W2146916411 hasConcept C95444343 @default.
• W2146916411 hasConcept C97029542 @default.
• W2146916411 hasConceptScore W2146916411C104317684 @default.
• W2146916411 hasConceptScore W2146916411C109650736 @default.
• W2146916411 hasConceptScore W2146916411C124320809 @default.

• next