FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146928689> ?p ?o ?g. }

• W2146928689 endingPage "2875" @default.
• W2146928689 startingPage "2865" @default.
• W2146928689 abstract "The current availability of five complete genomes of different primate species allows the analysis of genetic divergence over the last 40 million years of evolution. We hypothesized that the interspecies differences observed in susceptibility to HIV-1 would be influenced by the long-range selective pressures on host genes associated with HIV-1 pathogenesis. We established a list of human genes (n = 140) proposed to be involved in HIV-1 biology and pathogenesis and a control set of 100 random genes. We retrieved the orthologous genes from the genome of humans and of four nonhuman primates (Pan troglodytes, Pongo pygmaeus abeli, Macaca mulatta, and Callithrix jacchus) and analyzed the nucleotide substitution patterns of this data set using codon-based maximum likelihood procedures. In addition, we evaluated whether the candidate genes have been targets of recent positive selection in humans by analyzing HapMap Phase 2 single-nucleotide polymorphisms genotyped in a region centered on each candidate gene. A total of 1,064 sequences were used for the analyses. Similar median KA/KS values were estimated for the set of genes involved in HIV-1 pathogenesis and for control genes, 0.19 and 0.15, respectively. However, genes of the innate immunity had median values of 0.37 (P value = 0.0001, compared with control genes), and genes of intrinsic cellular defense had KA/KS values around or greater than 1.0 (P value = 0.0002). Detailed assessment allowed the identification of residues under positive selection in 13 proteins: AKT1, APOBEC3G, APOBEC3H, CD4, DEFB1, GML, IL4, IL8RA, L-SIGN/CLEC4M, PTPRC/CD45, Tetherin/BST2, TLR7, and TRIM5α. A number of those residues are relevant for HIV-1 biology. The set of 140 genes involved in HIV-1 pathogenesis did not show a significant enrichment in signals of recent positive selection in humans (intraspecies selection). However, we identified within or near these genes 24 polymorphisms showing strong signatures of recent positive selection. Interestingly, the DEFB1 gene presented signatures of both interspecies positive selection in primates and intraspecies recent positive selection in humans. The systematic assessment of long-acting selective pressures on primate genomes is a useful tool to extend our understanding of genetic variation influencing contemporary susceptibility to HIV-1." @default.
• W2146928689 created "2016-06-24" @default.
• W2146928689 creator A5012236358 @default.
• W2146928689 creator A5012546332 @default.
• W2146928689 creator A5014843347 @default.
• W2146928689 creator A5038713098 @default.
• W2146928689 creator A5043402793 @default.
• W2146928689 creator A5054186469 @default.
• W2146928689 creator A5055799358 @default.
• W2146928689 creator A5066398751 @default.
• W2146928689 date "2009-09-02" @default.
• W2146928689 modified "2023-10-17" @default.
• W2146928689 title "Evolutionary Trajectories of Primate Genes Involved in HIV Pathogenesis" @default.
• W2146928689 cites W1480780297 @default.
• W2146928689 cites W1564741855 @default.
• W2146928689 cites W1689369637 @default.
• W2146928689 cites W1965813248 @default.
• W2146928689 cites W1971226986 @default.
• W2146928689 cites W1972029847 @default.
• W2146928689 cites W1972673599 @default.
• W2146928689 cites W1977300115 @default.
• W2146928689 cites W1987303272 @default.
• W2146928689 cites W1989887938 @default.
• W2146928689 cites W1990993204 @default.
• W2146928689 cites W1996423252 @default.
• W2146928689 cites W2001375348 @default.
• W2146928689 cites W2002039213 @default.
• W2146928689 cites W2007049562 @default.
• W2146928689 cites W2010458160 @default.
• W2146928689 cites W2013556374 @default.
• W2146928689 cites W2014606320 @default.
• W2146928689 cites W2016732725 @default.
• W2146928689 cites W2017777683 @default.
• W2146928689 cites W2025253353 @default.
• W2146928689 cites W2027613370 @default.
• W2146928689 cites W2028942681 @default.
• W2146928689 cites W2036374978 @default.
• W2146928689 cites W2047495447 @default.
• W2146928689 cites W2058171566 @default.
• W2146928689 cites W2059288327 @default.
• W2146928689 cites W2068880841 @default.
• W2146928689 cites W2070119291 @default.
• W2146928689 cites W2072662088 @default.
• W2146928689 cites W2081557334 @default.
• W2146928689 cites W2082314789 @default.
• W2146928689 cites W2088422296 @default.
• W2146928689 cites W2091107017 @default.
• W2146928689 cites W2092768543 @default.
• W2146928689 cites W2098781795 @default.
• W2146928689 cites W2104669000 @default.
• W2146928689 cites W2104903168 @default.
• W2146928689 cites W2109595909 @default.
• W2146928689 cites W2116713053 @default.
• W2146928689 cites W2117790117 @default.
• W2146928689 cites W2119632499 @default.
• W2146928689 cites W2123584222 @default.
• W2146928689 cites W2132926880 @default.
• W2146928689 cites W2134995548 @default.
• W2146928689 cites W2136145671 @default.
• W2146928689 cites W2136367805 @default.
• W2146928689 cites W2138468602 @default.
• W2146928689 cites W2139119391 @default.
• W2146928689 cites W2144368480 @default.
• W2146928689 cites W2145848202 @default.
• W2146928689 cites W2149232113 @default.
• W2146928689 cites W2154770881 @default.
• W2146928689 cites W2156866331 @default.
• W2146928689 cites W2158829066 @default.
• W2146928689 cites W2160364329 @default.
• W2146928689 cites W2163031152 @default.
• W2146928689 cites W2170565120 @default.
• W2146928689 cites W2319346041 @default.
• W2146928689 doi "https://doi.org/10.1093/molbev/msp197" @default.
• W2146928689 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19726537" @default.
• W2146928689 hasPublicationYear "2009" @default.
• W2146928689 type Work @default.
• W2146928689 sameAs 2146928689 @default.
• W2146928689 citedByCount "51" @default.
• W2146928689 countsByYear W21469286892012 @default.
• W2146928689 countsByYear W21469286892013 @default.
• W2146928689 countsByYear W21469286892014 @default.
• W2146928689 countsByYear W21469286892015 @default.
• W2146928689 countsByYear W21469286892016 @default.
• W2146928689 countsByYear W21469286892017 @default.
• W2146928689 countsByYear W21469286892018 @default.
• W2146928689 countsByYear W21469286892020 @default.
• W2146928689 crossrefType "journal-article" @default.
• W2146928689 hasAuthorship W2146928689A5012236358 @default.
• W2146928689 hasAuthorship W2146928689A5012546332 @default.
• W2146928689 hasAuthorship W2146928689A5014843347 @default.
• W2146928689 hasAuthorship W2146928689A5038713098 @default.
• W2146928689 hasAuthorship W2146928689A5043402793 @default.
• W2146928689 hasAuthorship W2146928689A5054186469 @default.
• W2146928689 hasAuthorship W2146928689A5055799358 @default.
• W2146928689 hasAuthorship W2146928689A5066398751 @default.
• W2146928689 hasBestOaLocation W21469286891 @default.
• W2146928689 hasConcept C104317684 @default.
• W2146928689 hasConcept C135763542 @default.

• next