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- W2146933058 abstract "CCR5-Maraviroc Structure The chemokine receptor CCR5, a G protein–coupled receptor best known as a co-receptor during HIV-1 infection, is important in a variety of physiological processes. Tan et al. (p. 1387 , published online 12 September; see the Perspective by Klasse ) now report the high-resolution crystal structure of CCR5 bound to the HIV-1 entry inhibitor, Maraviroc. The structure suggests that Maraviroc acts as a noncompetitive inhibitor by binding to a region of CCR5 that is distinct from the binding site of HIV-1 and chemokines. Comparison of the structure of CCR5 with the other HIV-1 co-receptor, the chemokine receptor CXCR4, provides insight into the co-receptor selectivity of the virus." @default.
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- W2146933058 date "2013-09-20" @default.
- W2146933058 modified "2023-10-09" @default.
- W2146933058 title "Structure of the CCR5 Chemokine Receptor–HIV Entry Inhibitor Maraviroc Complex" @default.
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- W2146933058 doi "https://doi.org/10.1126/science.1241475" @default.
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