Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146969589> ?p ?o ?g. }
- W2146969589 endingPage "585" @default.
- W2146969589 startingPage "576" @default.
- W2146969589 abstract "Abstract Parkinson's disease (PD) is the second most common neurodegenerative disease and is characterized by dopaminergic (DA) neuronal cell loss in the substantia nigra. Although the entire pathogenesis of PD is still unclear, both environmental and genetic factors contribute to neurodegeneration. Epidemiologic studies show that prevalence of PD is lower in smokers than in nonsmokers,. Nicotine, a releaser of dopamine from DA neurons, is one of the candidates of antiparkinson agents in tobacco. To assess the protective effect of nicotine against rotenone‐induced DA neuronal cell toxicity, we examined the neuroprotective effects of nicotine in rotenone‐induced PD models in vivo and in vitro. We observed that simultaneous subcutaneous administration of nicotine inhibited both motor deficits and DA neuronal cell loss in the substantia nigra of rotenone‐treated mice. Next, we analyzed the molecular mechanisms of DA neuroprotective effect of nicotine against rotenone‐induced toxicity with primary DA neuronal culture. We found that DA neuroprotective effects of nicotine were inhibited by dihydro‐β‐erythroidine (DHβE), α‐bungarotoxin (αBuTx), and/or PI3K‐Akt/PKB (protein serine/threonine kinase B) inhibitors, demonstrating that rotenone‐toxicity on DA neurons are inhibited via activation of α4β2 or α7 nAChRs‐PI3K‐Akt/PKB pathway or pathways. These results suggest that the rotenone mouse model may be useful for assessing candidate antiparkinson agents, and that nAChR (nicotinic acetylcholine receptor) stimulation can protect DA neurons against degeneration. © 2008 Wiley‐Liss, Inc." @default.
- W2146969589 created "2016-06-24" @default.
- W2146969589 creator A5001869606 @default.
- W2146969589 creator A5024903237 @default.
- W2146969589 creator A5026275950 @default.
- W2146969589 creator A5032064265 @default.
- W2146969589 creator A5032191719 @default.
- W2146969589 creator A5036976658 @default.
- W2146969589 creator A5043321188 @default.
- W2146969589 creator A5043762491 @default.
- W2146969589 creator A5047187786 @default.
- W2146969589 creator A5048153044 @default.
- W2146969589 creator A5061304175 @default.
- W2146969589 creator A5061628159 @default.
- W2146969589 creator A5074177770 @default.
- W2146969589 creator A5081384952 @default.
- W2146969589 creator A5088123955 @default.
- W2146969589 creator A5090966781 @default.
- W2146969589 date "2008-09-19" @default.
- W2146969589 modified "2023-10-15" @default.
- W2146969589 title "Nicotinic receptor stimulation protects nigral dopaminergic neurons in rotenone-induced Parkinson's disease models" @default.
- W2146969589 cites W104349838 @default.
- W2146969589 cites W1495696399 @default.
- W2146969589 cites W1504584187 @default.
- W2146969589 cites W1537745645 @default.
- W2146969589 cites W1567046997 @default.
- W2146969589 cites W1980854377 @default.
- W2146969589 cites W1981982642 @default.
- W2146969589 cites W1987446689 @default.
- W2146969589 cites W1987928754 @default.
- W2146969589 cites W1989910729 @default.
- W2146969589 cites W1994121039 @default.
- W2146969589 cites W1997468402 @default.
- W2146969589 cites W2003018102 @default.
- W2146969589 cites W2004123088 @default.
- W2146969589 cites W2004747758 @default.
- W2146969589 cites W2005023775 @default.
- W2146969589 cites W2005773839 @default.
- W2146969589 cites W2008156619 @default.
- W2146969589 cites W2013937696 @default.
- W2146969589 cites W2016905315 @default.
- W2146969589 cites W2017081050 @default.
- W2146969589 cites W2018211893 @default.
- W2146969589 cites W2019019227 @default.
- W2146969589 cites W2026840820 @default.
- W2146969589 cites W2027603848 @default.
- W2146969589 cites W2039232051 @default.
- W2146969589 cites W2039790609 @default.
- W2146969589 cites W2044175751 @default.
- W2146969589 cites W2047632293 @default.
- W2146969589 cites W2058826346 @default.
- W2146969589 cites W2059511731 @default.
- W2146969589 cites W2068712507 @default.
- W2146969589 cites W2073135164 @default.
- W2146969589 cites W2073251217 @default.
- W2146969589 cites W2082828572 @default.
- W2146969589 cites W2085594747 @default.
- W2146969589 cites W2091425360 @default.
- W2146969589 cites W2092042225 @default.
- W2146969589 cites W2093671206 @default.
- W2146969589 cites W2096991937 @default.
- W2146969589 cites W2097682864 @default.
- W2146969589 cites W2097894700 @default.
- W2146969589 cites W2103645895 @default.
- W2146969589 cites W2111405228 @default.
- W2146969589 cites W2114682795 @default.
- W2146969589 cites W2118825726 @default.
- W2146969589 cites W2134303854 @default.
- W2146969589 cites W2136372119 @default.
- W2146969589 cites W2152151244 @default.
- W2146969589 cites W2158905357 @default.
- W2146969589 cites W2165027111 @default.
- W2146969589 cites W2169184332 @default.
- W2146969589 cites W4230177658 @default.
- W2146969589 cites W4294216491 @default.
- W2146969589 cites W99034421 @default.
- W2146969589 doi "https://doi.org/10.1002/jnr.21869" @default.
- W2146969589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18803299" @default.
- W2146969589 hasPublicationYear "2008" @default.
- W2146969589 type Work @default.
- W2146969589 sameAs 2146969589 @default.
- W2146969589 citedByCount "95" @default.
- W2146969589 countsByYear W21469695892012 @default.
- W2146969589 countsByYear W21469695892013 @default.
- W2146969589 countsByYear W21469695892014 @default.
- W2146969589 countsByYear W21469695892015 @default.
- W2146969589 countsByYear W21469695892016 @default.
- W2146969589 countsByYear W21469695892017 @default.
- W2146969589 countsByYear W21469695892018 @default.
- W2146969589 countsByYear W21469695892019 @default.
- W2146969589 countsByYear W21469695892020 @default.
- W2146969589 countsByYear W21469695892021 @default.
- W2146969589 countsByYear W21469695892022 @default.
- W2146969589 countsByYear W21469695892023 @default.
- W2146969589 crossrefType "journal-article" @default.
- W2146969589 hasAuthorship W2146969589A5001869606 @default.
- W2146969589 hasAuthorship W2146969589A5024903237 @default.
- W2146969589 hasAuthorship W2146969589A5026275950 @default.