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• W2146987694 abstract "To elucidate the molecular mechanism of frameshift suppression by the SUF2 gene of yeast, the sequences of DNA fragments carrying the SUF2-1 and suf2+ alleles of the gene and surrounding regions have been determined. Comparison of the suppressor and wild-type sequences indicates that the SUF2 gene product is a proline tRNA. Disregarding possible base modifications, we find that the wild-type suf2+ anticodon of the tRNA inferred from the DNA sequence is 3'-GGA-5'. The SUF2-1 mutation represents the insertion of a G-C base pair at a position in the gene that corresponds to the anticodon loop of the tRNA. Replacement of the wild-type suf2+ anticodon by a 3'-GGGA-5' fourbase anticodon enables the SUF2-1 tRNA to suppress the 5'-CCCU-3' four-base codons generated as the result of the his4-712 and his4-713 frameshift mutations. This nontriplet codon-anticodon interaction restores the correct reading frame and allows synthesis of a functional his4 protein." @default.
• W2146987694 created "2016-06-24" @default.
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• W2146987694 date "1982-06-01" @default.
• W2146987694 modified "2023-10-16" @default.
• W2146987694 title "Nucleotide sequence of the SUF2 frameshift suppressor gene of Saccharomyces cerevisiae." @default.
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• W2146987694 doi "https://doi.org/10.1073/pnas.79.11.3565" @default.
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