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- W214698920 abstract "Carcinostatic 1-(2-chloroethyl)-3-alkyl-1-nitrosoureas degrade to alkylating and carbamylating intermediates. Pharmacokinetic studies with these drugs have shown a complex pattern of metabolites that form within two min after drug administration to rats. CCNU+ half life is estimated to be less than five min in phenobarbital-induced rats. Monooxygenation of the cyclohexyl ring of CCNU occurred within two min and monohydroxylated CCNU metabolites were observed in all tissues examined. Covalent labeling was determined. Additional metabolites were observed that may result from nitroso group reduction. Spectral evidence for the participation of cytochrome P-450 in nitroso group reduction during the incubation of CCNU with microsomes and NADPH is presented. The consequence of metabolism of CCNU and Methyl CCNU prior to formation of alkylating and carbamylating intermediates is discussed." @default.
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- W214698920 date "1977-01-01" @default.
- W214698920 modified "2023-09-27" @default.
- W214698920 title "FORMATION OF ALKYLATION AND CARBAMYLATION INTERMEDIATES AND CYTOCHROME P-450 CATALYZED MONOOXYGENATION OF THE 2-CHLOROETHYLNITROSOUREAS CCNU AND METHYL CCNU" @default.
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- W214698920 doi "https://doi.org/10.1016/b978-0-08-021523-5.50094-8" @default.
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