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• W2146996710 abstract "Oxidative stress is the main factor in doxorubicin (DOX) induced cardiotoxicity. Wistar rats received either DOX (3 mg kg⁻¹, i.p.) every other day or combination of Hypericum hircinum (100 and 200 mg kg⁻¹, p.o.) and DOX or H. hircinum (200 mg kg⁻¹, p.o.) extract alone for 2 weeks. Cardiotoxicity was assessed by recording changes in ECG, heart rate and measuring the levels of cardiac marker enzymes--lactic acid dehydrogenase, creatine phosphokinase, glutamic oxaloacetic transaminase, the antioxidant defence enzymes--reduced glutathione (GSH), superoxide dismutase (SOD) and lipid peroxidative value (LPO) at the end of treatment schedule. Treatment with H. hircinum significantly (p < 0.05) decreased the levels of LPO and marker enzymes, increased the levels of GSH and SOD, reversed the changes in ECG and prevented the decrease in heart weight in DOX-treated group. The results suggest that H. hircinum has the potential to prevent the cardiotoxic effects induced by DOX." @default.
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• W2146996710 date "2013-08-01" @default.
• W2146996710 modified "2023-09-27" @default.
• W2146996710 title "Protective effect of<i>Hypericum hircinum</i>on doxorubicin-induced cardiotoxicity in rats" @default.
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• W2146996710 doi "https://doi.org/10.1080/14786419.2012.724409" @default.
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