Matches in SemOpenAlex for { <https://semopenalex.org/work/W2146997645> ?p ?o ?g. }
- W2146997645 endingPage "L736" @default.
- W2146997645 startingPage "L726" @default.
- W2146997645 abstract "In A549 cell culture, significant variability was found in sensitivity to actinomycin D. Using limiting dilution, actinomycin D-susceptible (G4S) and -resistant (D3R) subclones were isolated. G4S cells were also susceptible to protein synthesis inhibitors, a redox cycling quinone, and an electrophile with concomitant activation of caspases 3 and 9. D3R cells were resistant to these agents without caspase activation. Antioxidant profiles revealed that D3R cells had significantly higher glutathione and glutathione reductase activity but markedly lower catalase, glutathione peroxidase, and aldehyde reductase activities than G4S cells. Thus A549 cells contain at least two distinct subpopulations with respect to predisposition to cell death and antioxidant profile. Because sensitivities to agents and the antioxidant profile were inconsistent, mechanisms independent of antioxidants, including the apparent inability to activate caspases in D3R cells, may play an important role. Regardless, the results suggest that antioxidant profiles of asymmetrical cell populations cannot predict sensitivity to oxidants and warn that the use of single subclones is advisable for mechanistic studies using A549 or other unstable cell lines." @default.
- W2146997645 created "2016-06-24" @default.
- W2146997645 creator A5022475053 @default.
- W2146997645 creator A5028632015 @default.
- W2146997645 creator A5043578477 @default.
- W2146997645 creator A5070851241 @default.
- W2146997645 creator A5071870193 @default.
- W2146997645 creator A5086903497 @default.
- W2146997645 date "2002-10-01" @default.
- W2146997645 modified "2023-09-30" @default.
- W2146997645 title "A549 subclones demonstrate heterogeneity in toxicological sensitivity and antioxidant profile" @default.
- W2146997645 cites W1417333514 @default.
- W2146997645 cites W1487093108 @default.
- W2146997645 cites W1504571050 @default.
- W2146997645 cites W1543924337 @default.
- W2146997645 cites W1546592314 @default.
- W2146997645 cites W191793640 @default.
- W2146997645 cites W1940436875 @default.
- W2146997645 cites W1966986944 @default.
- W2146997645 cites W1972035122 @default.
- W2146997645 cites W1973129732 @default.
- W2146997645 cites W1986604347 @default.
- W2146997645 cites W1994318934 @default.
- W2146997645 cites W2011993914 @default.
- W2146997645 cites W2013911972 @default.
- W2146997645 cites W2032405173 @default.
- W2146997645 cites W2036338889 @default.
- W2146997645 cites W2037283275 @default.
- W2146997645 cites W2038658212 @default.
- W2146997645 cites W2039706098 @default.
- W2146997645 cites W2043541543 @default.
- W2146997645 cites W2046265680 @default.
- W2146997645 cites W2073159120 @default.
- W2146997645 cites W2075585144 @default.
- W2146997645 cites W2076477755 @default.
- W2146997645 cites W2078560674 @default.
- W2146997645 cites W2083671881 @default.
- W2146997645 cites W2085774270 @default.
- W2146997645 cites W2090306180 @default.
- W2146997645 cites W2092932922 @default.
- W2146997645 cites W2101422765 @default.
- W2146997645 cites W2102838769 @default.
- W2146997645 cites W2113999599 @default.
- W2146997645 cites W2148371829 @default.
- W2146997645 cites W2162441925 @default.
- W2146997645 cites W2167328736 @default.
- W2146997645 cites W2184733840 @default.
- W2146997645 cites W2197332903 @default.
- W2146997645 cites W2397382373 @default.
- W2146997645 cites W4254479325 @default.
- W2146997645 cites W49713821 @default.
- W2146997645 cites W937093307 @default.
- W2146997645 doi "https://doi.org/10.1152/ajplung.00025.2002" @default.
- W2146997645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12225949" @default.
- W2146997645 hasPublicationYear "2002" @default.
- W2146997645 type Work @default.
- W2146997645 sameAs 2146997645 @default.
- W2146997645 citedByCount "42" @default.
- W2146997645 countsByYear W21469976452012 @default.
- W2146997645 countsByYear W21469976452013 @default.
- W2146997645 countsByYear W21469976452015 @default.
- W2146997645 countsByYear W21469976452016 @default.
- W2146997645 countsByYear W21469976452017 @default.
- W2146997645 countsByYear W21469976452018 @default.
- W2146997645 countsByYear W21469976452019 @default.
- W2146997645 countsByYear W21469976452020 @default.
- W2146997645 countsByYear W21469976452021 @default.
- W2146997645 countsByYear W21469976452023 @default.
- W2146997645 crossrefType "journal-article" @default.
- W2146997645 hasAuthorship W2146997645A5022475053 @default.
- W2146997645 hasAuthorship W2146997645A5028632015 @default.
- W2146997645 hasAuthorship W2146997645A5043578477 @default.
- W2146997645 hasAuthorship W2146997645A5070851241 @default.
- W2146997645 hasAuthorship W2146997645A5071870193 @default.
- W2146997645 hasAuthorship W2146997645A5086903497 @default.
- W2146997645 hasConcept C153911025 @default.
- W2146997645 hasConcept C165069038 @default.
- W2146997645 hasConcept C181199279 @default.
- W2146997645 hasConcept C185592680 @default.
- W2146997645 hasConcept C190283241 @default.
- W2146997645 hasConcept C2778004101 @default.
- W2146997645 hasConcept C2778760513 @default.
- W2146997645 hasConcept C2778979269 @default.
- W2146997645 hasConcept C31573885 @default.
- W2146997645 hasConcept C538909803 @default.
- W2146997645 hasConcept C55493867 @default.
- W2146997645 hasConcept C81729549 @default.
- W2146997645 hasConcept C86803240 @default.
- W2146997645 hasConcept C98424977 @default.
- W2146997645 hasConceptScore W2146997645C153911025 @default.
- W2146997645 hasConceptScore W2146997645C165069038 @default.
- W2146997645 hasConceptScore W2146997645C181199279 @default.
- W2146997645 hasConceptScore W2146997645C185592680 @default.
- W2146997645 hasConceptScore W2146997645C190283241 @default.
- W2146997645 hasConceptScore W2146997645C2778004101 @default.
- W2146997645 hasConceptScore W2146997645C2778760513 @default.
- W2146997645 hasConceptScore W2146997645C2778979269 @default.
- W2146997645 hasConceptScore W2146997645C31573885 @default.